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Role of TLR4 signaling in the nephrotoxicity of Heme and heme proteins
Karl A. Nath
,
John D. Belcher
, Meryl C. Nath
, Joseph P. Grande
, Anthony J. Croatt
, Allan W. Ackerman
, Zvonimir S. Katusic
,
Gregory M. Vercellotti
Medicine - Hematology, Oncology, Transplant
Research output
:
Contribution to journal
›
Article
›
peer-review
36
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Scopus citations
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Dive into the research topics of 'Role of TLR4 signaling in the nephrotoxicity of Heme and heme proteins'. Together they form a unique fingerprint.
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Keyphrases
Toll-like
100%
Heme
100%
Nephrotoxicity
100%
Heme Proteins
100%
TAK-242
46%
Acute Kidney Injury
23%
Monocyte Chemoattractant protein-1 (MCP-1)
15%
Glycerol
15%
Renal Blood Flow
15%
Inflammatory Effects
15%
Downstream Genes
15%
Anti-inflammatory Effect
7%
Heme oxygenase-1 (HO-1)
7%
Kidney
7%
Intravenous Administration
7%
Induced Activation
7%
Inflammatory Response
7%
Flow Response
7%
Free Heme
7%
NF-B
7%
Renal Tubular Epithelial Cells
7%
Injury Model
7%
Renal Vasoconstriction
7%
Protein Release
7%
Transcription Factor Nrf2
7%
Inflammatory Transcription Factors
7%
Independent Pathway
7%
Histological Injuries
7%
Pharmacology, Toxicology and Pharmaceutical Science
Nephrotoxicity
100%
Toll Like Receptor 4
100%
Hemoprotein
100%
Heme
100%
Acute Kidney Failure
21%
Receptor
14%
Monocyte Chemotactic Protein 1
14%
Antiinflammatory Activity
7%
Anti-Inflammatory Drug
7%
Heme Oxygenase 1
7%
Transcription Factor Nrf2
7%
Inflammation
7%
Biochemistry, Genetics and Molecular Biology
Hemoprotein
100%
Hemeprotein
100%
TLR4
100%
Acute Kidney Failure
27%
Glycerol
18%
Kidney Blood Flow
18%
Synapsin I
18%
Independent Pathway
9%
Agonist
9%
Upregulation
9%
Vasoconstriction
9%
Antiinflammatory Activity
9%
Protein Secretion
9%
Transcription Factor Nrf2
9%
Heme Oxygenase
9%
Anti-Inflammatory
9%
Neuroscience
TLR 4
100%
Heme
100%
Hemoprotein
100%
In Vivo
14%
Anti-Inflammatory
14%
In Vitro
14%
Monocyte Chemotactic Protein 1
14%
Receptor
14%
Epithelial Cells
7%
Agonist
7%
Heme Oxygenase 1
7%
Transcription Factor Nrf2
7%