Role of the non-opioid dynorphin peptide des-Tyr-dynorphin (DYN-A2-17) in food intake and physical activity, and its interaction with orexin-A.

L. Gac, T. A. Butterick, C. M. Duffy, Jennifer A Teske, Claudio E Perez Leighton

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Food intake and physical activity are regulated by multiple neuropeptides, including orexin and dynorphin (DYN). Orexin-A (OXA) is one of two orexin peptides with robust roles in regulation of food intake and spontaneous physical activity (SPA). DYN collectively refers to several peptides, some of which act through opioid receptors (opioid DYN) and some whose biological effects are not mediated by opioid receptors (non-opioid DYN). While opioid DYN is known to increase food intake, the effects of non-opioid DYN peptides on food intake and SPA are unknown. Neurons that co-express and release OXA and DYN are located within the lateral hypothalamus. Limited evidence suggests that OXA and opioid DYN peptides can interact to modulate some aspects of behaviors classically related to orexin peptide function. The paraventricular hypothalamic nucleus (PVN) is a brain area where OXA and DYN peptides might interact to modulate food intake and SPA. We demonstrate that injection of des-Tyr-dynorphin (DYN-A2-17, a non opioid DYN peptide) into the PVN increases food intake and SPA in adult mice. Co-injection of DYN-A2-17 and OXA in the PVN further increases food intake compared to DYN-A2-17 or OXA alone. This is the first report describing the effects of non-opioid DYN-A2-17 on food intake and SPA, and suggests that DYN-A2-17 interacts with OXA in the PVN to modulate food intake. Our data suggest a novel function for non-opioid DYN-A2-17 on food intake, supporting the concept that some behavioral effects of the orexin neurons result from combined actions of the orexin and DYN peptides.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
StatePublished - Feb 1 2016

Bibliographical note

Funding Information:
This study and CPL were supported by grants from CONICYT Programa de Atracción de Científicos desde el Extranjero 82130017 and CONICYT Programa FONDECYT Regular 1150274 . Jennifer A. Teske is supported by the Department of Veterans Affairs (F7212W) and the United States Department of Agriculture (ARZT-1360220-H23-150). Tammy A. Butterick is supported by the Department of Veterans Affairs BLDR&D BX001686. The authors would like to thank Marjorie Sarmiento for her help in data collection.

Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.


  • Dynorphin
  • Food intake
  • Hypocretin
  • Hypothalamus
  • Orexin
  • PVN
  • Physical activity
  • des-Tyr-dynorphin


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