Role of the adiponectin leptin ratio in prostate cancer

Michael E. Grossmann, Nancy K. Mizuno, Melissa J.L. Bonorden, Amitabha Ray, Irina Sokolchik, Meena L. Narasimhan, Margot P. Cleary

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22 Scopus citations

Abstract

We hypothesize that adiponectin and leptin may be capable of mediating some of the effects that body weight has on prostate cancer and that a mouse model may be effective to examine this hypothesis. We found that tumors from the TRAMP prostate cancer model expressed adiponectin and leptin receptors. TRAMP-C2 prostate cancer cell proliferation was reduced by adiponectin. Leptin was able to block the ability of adiponectin to reduce cell proliferation through altered signaling of the ERK pathway. Overall, this work suggests that adiponectin, leptin, and their receptors may play an important role in prostate cancer.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalOncology Research
Volume18
Issue number5-6
DOIs
StatePublished - Dec 1 2009

Keywords

  • Adiponectin
  • Leptin
  • Osmotin
  • Prostate cancer
  • TRAMP mice
  • TRAMP-C2 cells

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    Grossmann, M. E., Mizuno, N. K., Bonorden, M. J. L., Ray, A., Sokolchik, I., Narasimhan, M. L., & Cleary, M. P. (2009). Role of the adiponectin leptin ratio in prostate cancer. Oncology Research, 18(5-6), 269-277. https://doi.org/10.3727/096504009X12596189659367