Role of the adiponectin leptin ratio in prostate cancer

Michael E. Grossmann, Nancy K. Mizuno, Melissa J.L. Bonorden, Amitabha Ray, Irina Sokolchik, Meena L. Narasimhan, Margot P. Cleary

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We hypothesize that adiponectin and leptin may be capable of mediating some of the effects that body weight has on prostate cancer and that a mouse model may be effective to examine this hypothesis. We found that tumors from the TRAMP prostate cancer model expressed adiponectin and leptin receptors. TRAMP-C2 prostate cancer cell proliferation was reduced by adiponectin. Leptin was able to block the ability of adiponectin to reduce cell proliferation through altered signaling of the ERK pathway. Overall, this work suggests that adiponectin, leptin, and their receptors may play an important role in prostate cancer.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalOncology Research
Volume18
Issue number5-6
DOIs
StatePublished - Dec 1 2009

Fingerprint

Adiponectin
Leptin
Prostatic Neoplasms
Leptin Receptors
Adiponectin Receptors
Cell Proliferation
MAP Kinase Signaling System
Body Weight
Neoplasms

Keywords

  • Adiponectin
  • Leptin
  • Osmotin
  • Prostate cancer
  • TRAMP mice
  • TRAMP-C2 cells

Cite this

Grossmann, M. E., Mizuno, N. K., Bonorden, M. J. L., Ray, A., Sokolchik, I., Narasimhan, M. L., & Cleary, M. P. (2009). Role of the adiponectin leptin ratio in prostate cancer. Oncology Research, 18(5-6), 269-277. https://doi.org/10.3727/096504009X12596189659367

Role of the adiponectin leptin ratio in prostate cancer. / Grossmann, Michael E.; Mizuno, Nancy K.; Bonorden, Melissa J.L.; Ray, Amitabha; Sokolchik, Irina; Narasimhan, Meena L.; Cleary, Margot P.

In: Oncology Research, Vol. 18, No. 5-6, 01.12.2009, p. 269-277.

Research output: Contribution to journalArticle

Grossmann, ME, Mizuno, NK, Bonorden, MJL, Ray, A, Sokolchik, I, Narasimhan, ML & Cleary, MP 2009, 'Role of the adiponectin leptin ratio in prostate cancer', Oncology Research, vol. 18, no. 5-6, pp. 269-277. https://doi.org/10.3727/096504009X12596189659367
Grossmann ME, Mizuno NK, Bonorden MJL, Ray A, Sokolchik I, Narasimhan ML et al. Role of the adiponectin leptin ratio in prostate cancer. Oncology Research. 2009 Dec 1;18(5-6):269-277. https://doi.org/10.3727/096504009X12596189659367
Grossmann, Michael E. ; Mizuno, Nancy K. ; Bonorden, Melissa J.L. ; Ray, Amitabha ; Sokolchik, Irina ; Narasimhan, Meena L. ; Cleary, Margot P. / Role of the adiponectin leptin ratio in prostate cancer. In: Oncology Research. 2009 ; Vol. 18, No. 5-6. pp. 269-277.
@article{5c6972e7f2c945faab25019fc7c0c49e,
title = "Role of the adiponectin leptin ratio in prostate cancer",
abstract = "We hypothesize that adiponectin and leptin may be capable of mediating some of the effects that body weight has on prostate cancer and that a mouse model may be effective to examine this hypothesis. We found that tumors from the TRAMP prostate cancer model expressed adiponectin and leptin receptors. TRAMP-C2 prostate cancer cell proliferation was reduced by adiponectin. Leptin was able to block the ability of adiponectin to reduce cell proliferation through altered signaling of the ERK pathway. Overall, this work suggests that adiponectin, leptin, and their receptors may play an important role in prostate cancer.",
keywords = "Adiponectin, Leptin, Osmotin, Prostate cancer, TRAMP mice, TRAMP-C2 cells",
author = "Grossmann, {Michael E.} and Mizuno, {Nancy K.} and Bonorden, {Melissa J.L.} and Amitabha Ray and Irina Sokolchik and Narasimhan, {Meena L.} and Cleary, {Margot P.}",
year = "2009",
month = "12",
day = "1",
doi = "10.3727/096504009X12596189659367",
language = "English (US)",
volume = "18",
pages = "269--277",
journal = "Oncology Research",
issn = "0965-0407",
publisher = "Cognizant Communication Corporation",
number = "5-6",

}

TY - JOUR

T1 - Role of the adiponectin leptin ratio in prostate cancer

AU - Grossmann, Michael E.

AU - Mizuno, Nancy K.

AU - Bonorden, Melissa J.L.

AU - Ray, Amitabha

AU - Sokolchik, Irina

AU - Narasimhan, Meena L.

AU - Cleary, Margot P.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - We hypothesize that adiponectin and leptin may be capable of mediating some of the effects that body weight has on prostate cancer and that a mouse model may be effective to examine this hypothesis. We found that tumors from the TRAMP prostate cancer model expressed adiponectin and leptin receptors. TRAMP-C2 prostate cancer cell proliferation was reduced by adiponectin. Leptin was able to block the ability of adiponectin to reduce cell proliferation through altered signaling of the ERK pathway. Overall, this work suggests that adiponectin, leptin, and their receptors may play an important role in prostate cancer.

AB - We hypothesize that adiponectin and leptin may be capable of mediating some of the effects that body weight has on prostate cancer and that a mouse model may be effective to examine this hypothesis. We found that tumors from the TRAMP prostate cancer model expressed adiponectin and leptin receptors. TRAMP-C2 prostate cancer cell proliferation was reduced by adiponectin. Leptin was able to block the ability of adiponectin to reduce cell proliferation through altered signaling of the ERK pathway. Overall, this work suggests that adiponectin, leptin, and their receptors may play an important role in prostate cancer.

KW - Adiponectin

KW - Leptin

KW - Osmotin

KW - Prostate cancer

KW - TRAMP mice

KW - TRAMP-C2 cells

UR - http://www.scopus.com/inward/record.url?scp=77951212492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951212492&partnerID=8YFLogxK

U2 - 10.3727/096504009X12596189659367

DO - 10.3727/096504009X12596189659367

M3 - Article

VL - 18

SP - 269

EP - 277

JO - Oncology Research

JF - Oncology Research

SN - 0965-0407

IS - 5-6

ER -