Role of surface modification on the culture and transduction of hematopoietic cells for gene therapy

Allison Hubel, Amy Williams, Jeffrey McCullough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The role of surface composition on the ability of hematopoietic progenitor cells to be transduced with retroviral vectors was examined. Human hematopoietic progenitor cells (CD34+cells) were transduced with retroviral vector LNGFR. The cells were tested for the percentage of cells expressing LNGFR. The results indicate that the percentage of hematopoietic progenitor cells is increased with increasing concentration of extracellular matrix molecules.

Original languageEnglish (US)
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages7-8
Number of pages2
Volume42
ISBN (Print)0791816117
StatePublished - Dec 1 1999
Event1999 Bioengineering Conference - Big Sky, MT, USA
Duration: Jun 16 1999Jun 20 1999

Other

Other1999 Bioengineering Conference
CityBig Sky, MT, USA
Period6/16/996/20/99

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