Role of redox signaling and inflammation in skeletal muscle adaptations to training

Maria Carmen Gomez-Cabrera, Jose Viña, Li Li Ji

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


The inflammatory response to exercise-induced muscle damage has been extensively described. Exercise has important modulatory effects on immune function. These effects are mediated by diverse factors including pro-inflammatory cytokines, classical stress hormones, and hemodynamic effects leading to cell redistribution. As has been reported regarding oxidative stress, inflammation can have both detrimental and beneficial effects in skeletal muscle. In this review we will address the role of inflammation on protein metabolism in skeletal muscle. Specifically, we will review studies showing that treatment with cyclooxygenase-inhibiting drugs modulate the protein synthesis response to one bout of resistance exercise and to training. Understanding how these drugs work is important for the millions of individuals worldwide that consume them regularly. We will also discuss the importance of reactive oxygen species and inflammatory cytokines in muscle adaptations to exercise and the Janus faced of the use of antioxidant and anti-inflammatory drugs by athletes for optimizing their performance, especially during the periods in which muscle hypertrophy is expected.

Original languageEnglish (US)
Article number48
Issue number4
StatePublished - Dec 2016

Bibliographical note

Funding Information:
This research has been supported by the University of Valencia that granted MC G-C with a short visit grant with reference: UV-INV-EPDI16-384590. The funder had no role in the preparation on the decision to publish

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.


  • Anti-inflammatories
  • Hypertrophy
  • Oxidative stress
  • Prostaglandins
  • Protein synthesis


Dive into the research topics of 'Role of redox signaling and inflammation in skeletal muscle adaptations to training'. Together they form a unique fingerprint.

Cite this