ROLE OF POLYMER MATRIX STRUCTURE AND INTERPARTICLE INTERACTIONS IN DIFFUSION LIMITED DRUG RELEASE.

Anna C. Balazs, Daniel F. Calef, J. M. Deutch, Ronald A. Siegel, Robert Langer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This investigation used a lattice random walk model to simulate diffusion in a porous polymer, and analyzed the effect of some parameters of the polymer matrix structure, such as the length and width of the connecting constrictions, which contribute to the slowness of the transient kinetics. This model has the advantage of allowing one to consider the complicated geometries involved, as well as incorporating the nonsteady state aspect of this problem.

Original languageEnglish (US)
Title of host publicationPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Material
PublisherACS
Pages47-51
Number of pages5
Volume51
StatePublished - Dec 1 1984

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    Balazs, A. C., Calef, D. F., Deutch, J. M., Siegel, R. A., & Langer, R. (1984). ROLE OF POLYMER MATRIX STRUCTURE AND INTERPARTICLE INTERACTIONS IN DIFFUSION LIMITED DRUG RELEASE. In Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Material (Vol. 51, pp. 47-51). ACS.