The weak relationship between left ventricular function and exercise capacity in heart failure has stimulated interest in neurohumoral mechanisms as possibly contributing to exercise intolerance. Although chronic activation of neuroendocrine systems is characteristic of heart failure and is accompanied by impaired reflex responsiveness to physiologic stimuli, data from clinical trials do not support the hypothesis that the abnormal neurohumoral state is directly related to exercise intolerance. Thus, these systems may play an important role in the natural history of the disease and its high mortality, but they may not be critical to the impaired exercise capacity.
|Original language||English (US)|
|Issue number||5 SUPPL.|
|State||Published - 1992|
Bibliographical noteFunding Information:
Supported in part by a Program Project grant P01-HL32427 from the National Heart, Lung and Blood Institute, Bethesda, Md.