Role of Microglia in Ataxias

Austin Ferro, Carrie Sheeler, Juao Guilherme Rosa, Marija Cvetanovic

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Microglia, the resident macrophages of the central nervous system, critically influence neural function during development and in adulthood. Microglia are also profoundly sensitive to insults to the brain to which they respond with process of activation that includes spectrum of changes in morphology, function, and gene expression. Ataxias are a class of neurodegenerative diseases characterized by motor discoordination and predominant cerebellar involvement. In case of inherited forms of ataxia, mutant proteins are expressed throughout the brain and it is unclear why cerebellum is particularly vulnerable. Recent studies demonstrated that cerebellar microglia have a uniquely hyper-vigilant immune phenotype compared to microglia from other brain regions. These findings may indicate that microglia actively contribute to cerebellar vulnerability in ataxias. Here we review current knowledge about cerebellar microglia, their activation, and their role in the pathogenesis of ataxias. In addition, we briefly review advantages and disadvantages of several experimental approaches available to study microglia.

Original languageEnglish (US)
Pages (from-to)1792-1804
Number of pages13
JournalJournal of Molecular Biology
Volume431
Issue number9
DOIs
StatePublished - Apr 19 2019

Bibliographical note

Funding Information:
This work was funded by the Cvetanovic laboratory start-up fund from the Department of Neuroscience and Institute for the Translational Neuroscience .

Keywords

  • Ataxia
  • Purkinje neurons
  • cerebellum
  • glia
  • microglia

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