Role of Mannheimia haemolytica leukotoxin in the pathogenesis of bovine pneumonic pasteurellosis.

Samithamby Jeyaseelan, Srinand Sreevatsan, Samuel K. Maheswaran

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations


Bovine pneumonic pasteurellosis continues to be a major respiratory disease in feedlot cattle despite the recent advances in our understanding of the underlying complexities of causation. The etiological agent, Mannheimia haemolytica, possesses several virulence factors, including capsule, outer membrane proteins, adhesins, neuraminidase, endotoxin and exotoxic leukotoxin. Accumulating scientific evidence implicates leukotoxin as the primary factor contributing to clinical presentation and lung injury associated with this disease. Unlike other virulence factors, leukotoxin shows cell-type- and species-specific effects on bovine leukocytes. Recent investigations have delineated the mechanisms underlying the target-cell-specificity of leukotoxin and how this contributes to the pathogenesis of lung damage. This review summarizes current understanding of the secretion, regulation, mechanisms of action and evolutionary diversity of leukotoxin of M. haemolytica. Understanding the precise molecular mechanisms of leukotoxin is critical for the development of more effective prophylactic and therapeutic strategies to control this complex disease.

Original languageEnglish (US)
Pages (from-to)69-82
Number of pages14
JournalAnimal health research reviews / Conference of Research Workers in Animal Diseases
Issue number2
StatePublished - Dec 2002

Bibliographical note

Funding Information:
The authors would like to thank Drs Mathur Kannan and Shih-Ling Hsuan for many helpful discussions and Dr Dennis Foss for critical reading of the review. SJ is indebted to the University of Minnesota for a Liz-Atac Fellowship and to Yale University for a James Hudson Brown-Alexander Brown Coxe Postdoctoral Fellowship.


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