Abstract
Anorexia nervosa is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. To determine the potential role of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) in anorexia nervosa, serum concentrations of these cytokines were measured in patients with anorexia nervosa during starvation and after weight gain. Serum IL-6 and TGF-β concentrations were both significantly elevated during starvation and returned to levels comparable to those of normal-weight controls by the end of therapy. In contrast, serum TNF-α levels were undetectable in all patients and controls. Cytokines may play previously unsuspected roles in anorexia nervosa and its complications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 836-839 |
| Number of pages | 4 |
| Journal | Biological Psychiatry |
| Volume | 36 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 15 1994 |
Keywords
- anorexia nervosa
- Cytokines
- eating disorders
- interleukin-6
- transforming growth factor-β
- tumor necrosis factor
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