Role of interleukin-6 and transforming growth factor-β in anorexia nervosa

Claire Pomeroy; Elke Eckert; Shuxian Hu; Beth Eiken; Margaret Mentink; Ross D. Crosby; Chun C. Chao

doi:10.1016/0006-3223(94)90594-0

Role of interleukin-6 and transforming growth factor-β in anorexia nervosa

Claire Pomeroy, Elke Eckert, Shuxian Hu, Beth Eiken, Margaret Mentink, Ross D. Crosby, Chun C. Chao

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Abstract

Anorexia nervosa is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. To determine the potential role of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) in anorexia nervosa, serum concentrations of these cytokines were measured in patients with anorexia nervosa during starvation and after weight gain. Serum IL-6 and TGF-β concentrations were both significantly elevated during starvation and returned to levels comparable to those of normal-weight controls by the end of therapy. In contrast, serum TNF-α levels were undetectable in all patients and controls. Cytokines may play previously unsuspected roles in anorexia nervosa and its complications.

Original language	English (US)
Pages (from-to)	836-839
Number of pages	4
Journal	Biological Psychiatry
Volume	36
Issue number	12
DOIs	https://doi.org/10.1016/0006-3223(94)90594-0
State	Published - Dec 15 1994

Keywords

anorexia nervosa
Cytokines
eating disorders
interleukin-6
transforming growth factor-β
tumor necrosis factor

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10.1016/0006-3223(94)90594-0

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abstract = "Anorexia nervosa is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. To determine the potential role of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) in anorexia nervosa, serum concentrations of these cytokines were measured in patients with anorexia nervosa during starvation and after weight gain. Serum IL-6 and TGF-β concentrations were both significantly elevated during starvation and returned to levels comparable to those of normal-weight controls by the end of therapy. In contrast, serum TNF-α levels were undetectable in all patients and controls. Cytokines may play previously unsuspected roles in anorexia nervosa and its complications.",

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AU - Pomeroy, Claire

AU - Eckert, Elke

AU - Hu, Shuxian

AU - Eiken, Beth

AU - Mentink, Margaret

AU - Crosby, Ross D.

AU - Chao, Chun C.

PY - 1994/12/15

Y1 - 1994/12/15

N2 - Anorexia nervosa is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. To determine the potential role of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) in anorexia nervosa, serum concentrations of these cytokines were measured in patients with anorexia nervosa during starvation and after weight gain. Serum IL-6 and TGF-β concentrations were both significantly elevated during starvation and returned to levels comparable to those of normal-weight controls by the end of therapy. In contrast, serum TNF-α levels were undetectable in all patients and controls. Cytokines may play previously unsuspected roles in anorexia nervosa and its complications.

AB - Anorexia nervosa is a serious eating disorder characterized by extreme weight loss and abnormalities of the neuroendocrine and immune systems. To determine the potential role of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) in anorexia nervosa, serum concentrations of these cytokines were measured in patients with anorexia nervosa during starvation and after weight gain. Serum IL-6 and TGF-β concentrations were both significantly elevated during starvation and returned to levels comparable to those of normal-weight controls by the end of therapy. In contrast, serum TNF-α levels were undetectable in all patients and controls. Cytokines may play previously unsuspected roles in anorexia nervosa and its complications.

KW - anorexia nervosa

KW - Cytokines

KW - eating disorders

KW - interleukin-6

KW - transforming growth factor-β

KW - tumor necrosis factor

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Role of interleukin-6 and transforming growth factor-β in anorexia nervosa

Abstract

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