Role of Insulin-Like Growth Factor Receptors in Cancer Signaling

Douglas Yee

doi:10.1007/978-3-319-95228-4_22

Role of Insulin-Like Growth Factor Receptors in Cancer Signaling

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The insulin-like growth factor signaling system has been implicated in cancer etiology, progression, and metastasis. This signaling system involves a network of highly related ligands and receptors. Targeting of this system is complex; multiple receptors, including the insulin receptor, are involved. Further, holo- and hybrid receptors must be considered when considering therapeutic strategies. This review will evaluate the signaling pathways mediated by this system.

Original language	English (US)
Title of host publication	Predictive Biomarkers in Oncology
Subtitle of host publication	Applications in Precision Medicine
Publisher	Springer International Publishing
Pages	283-288
Number of pages	6
ISBN (Electronic)	9783319952284
ISBN (Print)	9783319952277
DOIs	https://doi.org/10.1007/978-3-319-95228-4_22
State	Published - Jan 1 2018

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2019.

Keywords

Insulin
Insulin receptor
Insulin-like growth factors
Type I insulin-like growth factor receptor
Tyrosine kinase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-95228-4_22

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KW - Insulin-like growth factors

KW - Type I insulin-like growth factor receptor

KW - Tyrosine kinase

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Role of Insulin-Like Growth Factor Receptors in Cancer Signaling

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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