The insulin-like growth factor signaling system has been implicated in cancer etiology, progression, and metastasis. This signaling system involves a network of highly related ligands and receptors. Targeting of this system is complex; multiple receptors, including the insulin receptor, are involved. Further, holo- and hybrid receptors must be considered when considering therapeutic strategies. This review will evaluate the signaling pathways mediated by this system.
|Original language||English (US)|
|Title of host publication||Predictive Biomarkers in Oncology|
|Subtitle of host publication||Applications in Precision Medicine|
|Publisher||Springer International Publishing|
|Number of pages||6|
|State||Published - Jan 1 2018|
Bibliographical notePublisher Copyright:
© Springer Nature Switzerland AG 2019.
- Insulin receptor
- Insulin-like growth factors
- Type I insulin-like growth factor receptor
- Tyrosine kinase