Role of Insulin-Like Growth Factor Receptors in Cancer Signaling

Research output: Chapter in Book/Report/Conference proceedingChapter


The insulin-like growth factor signaling system has been implicated in cancer etiology, progression, and metastasis. This signaling system involves a network of highly related ligands and receptors. Targeting of this system is complex; multiple receptors, including the insulin receptor, are involved. Further, holo- and hybrid receptors must be considered when considering therapeutic strategies. This review will evaluate the signaling pathways mediated by this system.

Original languageEnglish (US)
Title of host publicationPredictive Biomarkers in Oncology
Subtitle of host publicationApplications in Precision Medicine
PublisherSpringer International Publishing
Number of pages6
ISBN (Electronic)9783319952284
ISBN (Print)9783319952277
StatePublished - Jan 1 2018

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2019.


  • Insulin
  • Insulin receptor
  • Insulin-like growth factors
  • Type I insulin-like growth factor receptor
  • Tyrosine kinase


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