Abstract
Glycoproteins play a critical role in hostpathogen interactions, antigenicity, and virulence determination, and are therefore, considered as potential drug targets. The cell wall of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), dominantly contains sugars and lipids. Despite the efforts taken by the World Health Organization to reduce the incidence rate, the prevalence of TB is increasing in certain regions. This is mainly attributed to the emergence of multidrug-resistant bacteria. Factors that contribute to Mtb virulence and antigenicity remain elusive. However, several studies have shown that sugars and lipids are mainly responsible for Mtb pathogenesis and resistance to numerous drugs. This review gives insight into the role of glycoproteins in mycobacterium pathogenesis, disease development, and its implications in drug development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 250-266 |
| Number of pages | 17 |
| Journal | Critical Reviews in Microbiology |
| Volume | 38 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 2012 |
Bibliographical note
Funding Information:The authors would like to thank Prof. Peter Leuthy and the lab members for critical review of the manuscript. This work was supported by a grant from Indian Medical Research Council, Government of India to AS.
Keywords
- Drug target
- Glycoproteins
- Mycobacteria
- Pathogenesis
- Tuberculosis
