Role of Environment in Pediatric Rheumatic Diseases

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Studying environmental risk factors for pediatric rheumatic diseases (PRD) is important because the identification of these factors may lead to strategies to prevent disease, and to new insights into pathogenesis and therapeutic targets. Compared with other chronic diseases, there are few environmental epidemiology studies in PRD. Although strong risk factors common to all PRDs have not been identified, some exposures including infection, smoke exposure, and ultraviolet radiation have been associated with several of them. High-technology studies, especially of microbiomics and metabolomics, are increasing and will likely lead to new understandings of the complex interplay between environment, genetics, and disease.

Original languageEnglish (US)
Pages (from-to)287-304
Number of pages18
JournalRheumatic Disease Clinics of North America
Issue number1
StatePublished - Feb 2022
Externally publishedYes

Bibliographical note

Funding Information:
The author has nothing to disclose.


  • Environmental risk factors
  • Juvenile dermatomyositis
  • Juvenile idiopathic arthritis
  • Pediatric rheumatic diseases
  • Systemic lupus erythematosus

PubMed: MeSH publication types

  • Review
  • Journal Article


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