Role of endothelial-derived nitric oxide in normal and hypertensive pulmonary vasculature

S. Archer, V. Hampl, Z. McKenzie, D. Nelson, J. Huang, P. J. Shultz, Edward K Weir

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

The role of EDNO in the PHT has been primarily evaluated in animals, with few human studies. Most research has focused on the chronic hypoxic form of PHT. With these limitations in mind, we conclude that basal pulmonary EDNO synthesis is preserved or increased in PHT. Although this EDNO up-regulation seems to reduce the severity of PHT, its relative importance among other modulating factors remains to be established.

Original languageEnglish (US)
Pages (from-to)179-189
Number of pages11
JournalSeminars in Respiratory and Critical Care Medicine
Volume15
Issue number3
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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