Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity

Keyphrases

• Tyrosine 100%
• Cytochrome P450 2E1 (CYP2E1) 100%
• Protein Nitration 100%
• Acetaminophen Toxicity 100%
• Ubiquitin-mediated Degradation 100%
• Wild Mice 57%
• Null Mice 28%
• Protein Degradation 28%
• Inducible Nitric Oxide Synthase 28%
• Superoxide Dismutase 1 (SOD1) 28%
• Protein Adducts 28%
• Centrilobular 28%
• Nitrated Proteins 28%
• Biotransformation 14%
• In the Wild 14%
• Immunoblot Analysis 14%
• Native Protein 14%
• Nitration 14%
• Cytosolic Superoxide Dismutase 14%
• Liver Damage 14%
• Toxic Dose 14%
• Liver Necrosis 14%
• Short Half-life 14%
• Peroxynitrite 14%
• Acetaminophen APAP 14%
• Accelerated Degradation 14%
• Protein Ubiquitination 14%
• In(III) 14%

Pharmacology, Toxicology and Pharmaceutical Science

• CYP2E1 100%
• Ubiquitin 100%
• Paracetamol 100%
• Wild Type Mouse 80%
• Knockout Mouse 40%
• Nitric Oxide Synthase 40%
• Western Blot 20%
• Liver Injury 20%
• 3 Nitrotyrosine 20%
• Liver Necrosis 20%
• Peroxynitrite 20%
• Superoxide Dismutase 20%