Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis

Z. Chen, M. Han

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Vulval differentiation in Caenorhabditis elegans involves several fundamental cellular events, including cell fusion, division and migration. We have characterized the role of the lin-40 (also known as egr-1) gene in these cellular processes. LIN-40 is homologous to the metastasis-associated factor 1 (MTA1) in mammals, which has been identified as a component of the nucleosome remodeling and histone deacetylation (NuRD) complex that functions as a transcriptional co-repressor. We show here that lin-40 negatively regulates vulval fate specification at least partly by promoting cell fusion between the vulval precursor cells and the hypodermal syncytium at an early larval stage. This inhibitory function of lin-40 might be carried out by downregulating lin-39 Hox expression. We also show that lin-40 is specifically required for cell divisions along the transverse orientation during vulval morphogenesis.

Original languageEnglish (US)
Pages (from-to)4911-4921
Number of pages11
Issue number23
StatePublished - 2001
Externally publishedYes


  • C. elegans
  • Division orientation
  • Morphogenesis
  • VPCs competence
  • Vulval induction
  • lin-39 Hox
  • lin-40 MTA


Dive into the research topics of 'Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis'. Together they form a unique fingerprint.

Cite this