Role of Aurora B and Haspin kinases in the metaphase Topoisomerase II checkpoint

M. Johansson, Y. Azuma, D. J. Clarke

Research output: Contribution to journalArticlepeer-review

Abstract

DNA Topoisomerase II (TopoII) uses ATP hydrolysis to decatenate chromosomes so that sister chromatids can faithfully segregate in mitosis. When the TopoII enzyme cycle stalls due to failed ATP hydrolysis, the onset of anaphase is delayed, presumably to allow extra time for decatenation to be completed. Recent evidence revealed that, unlike the spindle assembly checkpoint, this TopoII checkpoint response requires Aurora B and Haspin kinases and is triggered by SUMOylation of the C-terminal domain of TopoII.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalCell Cycle
Volume20
Issue number4
DOIs
StatePublished - Feb 2021

Bibliographical note

Funding Information:
This work was supported in part by NIH/NIGMS GM112793 and GM130858.

Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Aurora B
  • Haspin
  • Topoisomerase II
  • checkpoint
  • mitosis

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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