Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Cristina García-Cáceres, Eglantine Balland, Vincent Prevot, Serge Luquet, Stephen C. Woods, Marco Koch, Tamas L. Horvath, Chun Xia Yi, Julia A. Chowen, Alexei Verkhratsky, Alfonso Araque, Ingo Bechmann, Matthias H. Tschöp

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations

Abstract

Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic feeding circuits. These non-neuronal cells are crucial in determining the functional interactions of specific neuronal subpopulations involved in the control of metabolism. Recent advances in biology, optics, genetics, and pharmacology have resulted in the emergence of novel and highly sophisticated approaches for studying hypothalamic neuronal–glial networks. Here we summarize the progress in the field and argue that glial–neuronal interactions provide a core hub integrating food-related cues, interoceptive signals, and internal states to adapt a complex set of physiological responses operating on different timescales to finely tune behavior and metabolism according to metabolic status. This expanding knowledge helps to redefine our understanding of the physiology of food intake and energy metabolism.

Original languageEnglish (US)
Pages (from-to)7-14
Number of pages8
JournalNature neuroscience
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2019

Bibliographical note

Funding Information:
This work was supported by European Research Council ERC AdG (HypoFlam no. 695054) to M.H.T. and ERC STG (AstroNeuroCrosstalk no. 757393) to C.G.-C.; ANR/ DFG Nutripathos Project ANR-15-CE14-0030-01/02 to M.H.T. and S.L.; the Deutsche Forschungsgemeinschaft (SFB 1052) Obesity Mechanisms to M.K. and I.B.; and the Agence National pour la Recherche (ANR) grant number ANR-15-CE14-0025 to V.P. and ANR-15-CE14-0030-01 and ANR-16-CE14-0026-02 to S.L.

Publisher Copyright:
© 2018, Springer Nature America, Inc.

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