Role for the unfolded protein response in heart disease and cardiac arrhythmias

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias.

Original languageEnglish (US)
Article number52
JournalInternational journal of molecular sciences
Volume17
Issue number1
DOIs
StatePublished - Dec 31 2015
Externally publishedYes

Keywords

  • ATF6α
  • Cardiac ion channels
  • Grp78
  • IRE1
  • Ischemia
  • PERK

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