Role for the unfolded protein response in heart disease and cardiac arrhythmias

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40 Scopus citations


The unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias.

Original languageEnglish (US)
Article number52
JournalInternational journal of molecular sciences
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.


  • ATF6α
  • Cardiac ion channels
  • Grp78
  • IRE1
  • Ischemia
  • PERK


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