Robust Iterative Stimulation with Self-Antigens Overcomes CD8⁺ T Cell Tolerance to Self- and Tumor Antigens

Keyphrases

• Tumor Antigen 100%
• T-cell Tolerance 100%
• CD8+ 100%
• Self-antigen 100%
• CD8+ T Cells 66%
• Tumor Immunity 66%
• Immune System 33%
• T Cells 33%
• Malignancy 33%
• Acute Infection 33%
• Self-tolerance 33%
• Autoimmunity 33%
• Cancer Treatment 33%
• Antigen-specific 33%
• Spur 33%
• Negative Selection 33%
• Tumor Neoantigens 33%
• Major Barriers 33%
• Therapeutic Applications 33%
• Resident Memory 33%
• Neoantigen-specific T Cells 33%
• Aggressive Melanoma 33%
• Tissue-restricted Antigens 33%

Immunology and Microbiology

• Antigen 100%
• Cytotoxic T-Cell 100%
• T-Cell Tolerance 100%
• Tumor Antigen 100%
• Antigen Specificity 50%
• Tumor Immunity 50%
• T Cell 50%
• Immune Tolerance 25%
• Autoimmunity 25%
• Neoantigen 25%
• Immune System 25%
• Infection 25%