Roadmap on plasticity and epigenetics in cancer

Jasmine Foo; David Basanta; Russell C. Rockne; Carly Strelez; Curran Shah; Kimya Ghaffarian; Shannon M. Mumenthaler; Kelly Mitchell; Justin D. Lathia; David Frankhouser; Sergio Branciamore; Ya Huei Kuo; Guido Marcucci; Robert Vander Velde; Andriy Marusyk; Sui Huang; Kishore Hari; Mohit Kumar Jolly; Haralampos Hatzikirou; Kamrine E. Poels; Mary E. Spilker; Blerta Shtylla; Mark Robertson-Tessi; Alexander R.A. Anderson

doi:10.1088/1478-3975/ac4ee2

Roadmap on plasticity and epigenetics in cancer

Jasmine Foo
, David Basanta
, Russell C. Rockne
, Carly Strelez
, Curran Shah
, Kimya Ghaffarian
, Shannon M. Mumenthaler
, Kelly Mitchell
, Justin D. Lathia
, David Frankhouser
, Sergio Branciamore
, Ya Huei Kuo
, Guido Marcucci
, Robert Vander Velde
, Andriy Marusyk
, Sui Huang
, Kishore Hari
, Mohit Kumar Jolly
, Haralampos Hatzikirou
, Kamrine E. Poels

Mary E. Spilker, Blerta Shtylla, Mark Robertson-Tessi, Alexander R.A. Anderson

School of Mathematics

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions: is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts?

Original language	English (US)
Article number	031501
Journal	Physical Biology
Volume	19
Issue number	3
DOIs	https://doi.org/10.1088/1478-3975/ac4ee2
State	Published - May 1 2022

Bibliographical note

Publisher Copyright:
Creative Commons Attribution license.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer
epigenetics
plasticity
Epigenomics
Epigenesis, Genetic
Humans
Neoplasms/drug therapy
Tumor Microenvironment
Mutation

PubMed: MeSH publication types

Review
Journal Article

Publisher link

10.1088/1478-3975/ac4ee2

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Foo, J., Basanta, D., Rockne, R. C., Strelez, C., Shah, C., Ghaffarian, K., Mumenthaler, S. M., Mitchell, K., Lathia, J. D., Frankhouser, D., Branciamore, S., Kuo, Y. H., Marcucci, G., Velde, R. V., Marusyk, A., Huang, S., Hari, K., Jolly, M. K., Hatzikirou, H., ... Anderson, A. R. A. (2022). Roadmap on plasticity and epigenetics in cancer. Physical Biology, 19(3), Article 031501. https://doi.org/10.1088/1478-3975/ac4ee2

Foo, J, Basanta, D, Rockne, RC, Strelez, C, Shah, C, Ghaffarian, K, Mumenthaler, SM, Mitchell, K, Lathia, JD, Frankhouser, D, Branciamore, S, Kuo, YH, Marcucci, G, Velde, RV, Marusyk, A, Huang, S, Hari, K, Jolly, MK, Hatzikirou, H, Poels, KE, Spilker, ME, Shtylla, B, Robertson-Tessi, M & Anderson, ARA 2022, 'Roadmap on plasticity and epigenetics in cancer', Physical Biology, vol. 19, no. 3, 031501. https://doi.org/10.1088/1478-3975/ac4ee2

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title = "Roadmap on plasticity and epigenetics in cancer",

abstract = "The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions: is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts?",

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doi = "10.1088/1478-3975/ac4ee2",

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AU - Mumenthaler, Shannon M.

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AU - Marcucci, Guido

AU - Velde, Robert Vander

AU - Marusyk, Andriy

AU - Huang, Sui

AU - Hari, Kishore

AU - Jolly, Mohit Kumar

AU - Hatzikirou, Haralampos

AU - Poels, Kamrine E.

AU - Spilker, Mary E.

AU - Shtylla, Blerta

AU - Robertson-Tessi, Mark

AU - Anderson, Alexander R.A.

N1 - Publisher Copyright: Creative Commons Attribution license.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions: is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts?

AB - The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical and experimental approaches to interrogate plasticity in cancer, and addresses the following themes and questions: is there a formal overarching framework that encompasses both non-genetic plasticity and mutation-driven somatic evolution? How do we measure and model the role of the microenvironment in influencing/controlling non-genetic plasticity? How can we experimentally study non-genetic plasticity? Which mathematical techniques are required or best suited? What are the clinical and practical applications and implications of these concepts?

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KW - epigenetics

KW - plasticity

KW - Epigenomics

KW - Epigenesis, Genetic

KW - Humans

KW - Neoplasms/drug therapy

KW - Tumor Microenvironment

KW - Mutation

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SN - 1478-3967

VL - 19

JO - Physical Biology

JF - Physical Biology

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ER -

Roadmap on plasticity and epigenetics in cancer

Abstract

Bibliographical note

UN SDGs

Keywords

PubMed: MeSH publication types

Publisher link

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