RO 15-4513 and FG 7142 reverse the reduction in social behavior caused by ethanol in mice

Leena A. Hilakivi, Richard G. Lister

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Ethanol (2 g/kg) reduces the time spent in social interaction and increases locomotor activity of pairs of NIH Swiss mice. This study examined whether two benzodiazepine receptor inverse agonists, RO 15-4513 (3 mg/kg) and FG 7142 (30 mg/kg) are able to reverse these effects. Neither drug alone altered social behavior, but both significantly attenuated the effect of ethanol on social interaction. They did not affect the ethanol-induced increase in motor activity. Benzodiazepine receptor inverse agonists thus appear capable of antagonizing some, but not all of the behavioral effects of ethanol in this paradigm.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalEuropean Journal of Pharmacology
Volume154
Issue number1
DOIs
StatePublished - Sep 1 1988
Externally publishedYes

Keywords

  • Benzodiazepine receptors
  • Ethanol
  • FG 7142
  • Motor activity
  • Ro 15-4513
  • Social behavior

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