Risk of multiple myeloma in a case-spouse study

Gabriella Andreotti, Michael Katz, Antje Hoering, Brian Van Ness, John Crowley, Gareth Morgan, Robert N. Hoover, Dalsu Baris, Brian Durie

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study examined lifestyle, occupation, medical history and medication use with multiple myeloma risk in a case-spouse study (481 patients, 351 spouses). Odds ratios (ORs) and 95% confidence intervals (CI) were calculated using logistic regression. Compared to spouse controls, cases were more likely to have a family history of multiple myeloma (OR = 2.8, 95% CI = 1.2-6.4) and smoked cigarettes (OR = 1.7, 95% CI = 1.2-2.5), but less likely to have consumed alcohol (OR = 0.6, 95% CI = 0.4-0.9). Nurse/health practitioners (OR = 2.8, 95% CI = 1.3-6.2) and production workers (OR = 3.7, 95% CI = 1.0-13.7) had significantly increased risks; and some occupations linked to diesel exhaust had elevated, but non-significant, risks. History of herpes simplex (OR = 1.7, 95% CI = 1.2-2.4), shingles (OR = 1.7, 95% CI = 1.1-2.7), sexually transmitted diseases (OR = 2.0, 95% CI = 1.0-3.7) and medication allergies (OR = 1.7, 95% CI = 1.2-2.4) were associated with higher risks. Use of angiotensin-converting enzyme inhibitors, anti-convulsants, antidepressants, statins and diuretics were associated with reduced risks. The results are consistent with previous population-based studies and support the utility of patient databanks and spouse controls as a resource in epidemiologic research.

Original languageEnglish (US)
Pages (from-to)1450-1459
Number of pages10
JournalLeukemia and Lymphoma
Volume57
Issue number6
DOIs
StatePublished - Jun 2 2016

Bibliographical note

Funding Information:
This work was supported by the International Myeloma Foundation's Bank On A Cure? and the Intramural Research Program of the National Cancer Institute, National Institutes of Health.

Keywords

  • Myeloma
  • case-spouse
  • epidemiology

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