Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV

Jacqueline Neuhaus, Brian Angus, Justyna D. Kowalska, Alberto La Rosa, Jim Sampson, Deborah Wentworth, Amanda Mocroft

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


objectives: Among patients with HIV, the risk of death associated with different AIDS events has been quantified, but the risk of death associated with non-AIDS events has not been examined. We compared the risk of all-cause mortality following AIDS versus serious non-AIDS (SNA) events in the Strategies for Management of Antiretroviral Therapy (SMART) study and the Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT). Design: Data from 9583 HIV-infected participants, 5472 with a CD4 cell count more than 350 cells/μl enrolled in SMART and 4111 with a CD4 cell count 300 cells/μl or more enrolled in ESPRIT, were analyzed. Methods: Cumulative mortality 6 months after AIDS and SNA events (cardiovascular, renal, hepatic disease, and malignancies) was estimated using the Kaplan-Meier method. Cox models were used to estimate hazard ratios associated with AIDS and SNA events on the risk of death overall and by treatment group within study. Results: AIDS and SNA events occurred in 286 and 435 participants with 47 (16%) and 115 (26%) subsequent deaths, respectively. Six-month cumulative mortality was 4.7% [95% confidence interval (CI) 2.8-8.0] after experiencing an AIDS event and 13.4% (95% CI 10.5-17.0) after experiencing an SNA event. The adjusted hazard ratio for all-cause mortality for those who experienced AIDS versus those who did not was 4.9 (95% CI 3.6-6.8). The corresponding hazard ratio for SNA was 11.4 (95% CI 9.0-14.5) (P < 0.001 for difference in hazard ratios). Findings were similar for both treatment groups in SMART and both treatment groups in ESPRIT. Conclusion: Among HIV-infected persons with higher CD4 cell counts, SNA events occur more frequently and are associated with a greater risk of death than AIDS events. Future research should be aimed at comparing strategies to reduce morbidity and mortality associated with SNA events for HIV-infected persons.

Original languageEnglish (US)
Pages (from-to)697-706
Number of pages10
Issue number5
StatePublished - Mar 2010


  • Cardiovascular disease
  • HIV
  • Hepatic disease
  • Malignancies
  • Mortality
  • Renal disease


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