TY - JOUR
T1 - Risk of Adverse Outcomes Associated With Cardiac Sarcoidosis Diagnostic Schemes
AU - Cardiac Sarcoidosis Consortium
AU - Myadam, Rahul
AU - Crawford, Thomas C.
AU - Bogun, Frank M.
AU - Gu, Xiaokui
AU - Ellenbogen, Kenneth A.
AU - Jasti, Shilpa
AU - Chicos, Alexandru B.
AU - Roukoz, Henri
AU - Zimetbaum, Peter J.
AU - Kalbfleisch, Steven J.
AU - Murgatroyd, Francis D.
AU - Steckman, David A.
AU - Rosenfeld, Lynda E.
AU - Garlitski, Ann C.
AU - Soejima, Kyoko
AU - Bhan, Adarsh K.
AU - Vedantham, Vasanth
AU - Dickfeld, Timm Michael L.
AU - De Lurgio, David B.
AU - Platonov, Pyotr G.
AU - Zipse, Matthew M.
AU - Nishiuchi, Suguru
AU - Ortman, Matthew L.
AU - Narasimhan, Calambur
AU - Patton, Kristen K.
AU - Rosenthal, David G.
AU - Mukerji, Siddharth S.
AU - Hoogendoorn, Jarieke C.
AU - Zeppenfeld, Katja
AU - Sauer, William H.
AU - Kron, Jordana
N1 - Publisher Copyright:
© 2023 American College of Cardiology Foundation
PY - 2023/8
Y1 - 2023/8
N2 - Background: Multiple cardiac sarcoidosis (CS) diagnostic schemes have been published. Objectives: This study aims to evaluate the association of different CS diagnostic schemes with adverse outcomes. The diagnostic schemes evaluated were 1993, 2006, and 2017 Japanese criteria and the 2014 Heart Rhythm Society criteria. Methods: Data were collected from the Cardiac Sarcoidosis Consortium, an international registry of CS patients. Outcome events were any of the following: all-cause mortality, left ventricular assist device placement, heart transplantation, and appropriate implantable cardioverter-defibrillator therapy. Logistic regression analysis evaluated the association of outcomes with each CS diagnostic scheme. Results: A total of 587 subjects met the following criteria: 1993 Japanese (n = 310, 52.8%), 2006 Japanese (n = 312, 53.2%), 2014 Heart Rhythm Society (n = 480, 81.8%), and 2017 Japanese (n = 112, 19.1%). Patients who met the 1993 criteria were more likely to experience an event than patients who did not (n = 109 of 310, 35.2% vs n = 59 of 277, 21.3%; OR: 2.00; 95% CI: 1.38-2.90; P < 0.001). Similarly, patients who met the 2006 criteria were more likely to have an event than patients who did not (n = 116 of 312, 37.2% vs n = 52 of 275, 18.9%; OR: 2.54; 95% CI: 1.74-3.71; P < 0.001). There was no statistically significant association between the occurrence of an event and whether a patient met the 2014 or the 2017 criteria (OR: 1.39; 95% CI: 0.85-2.27; P = 0.18 or OR: 1.51; 95% CI: 0.97-2.33; P = 0.067, respectively). Conclusions: CS patients who met the 1993 and the 2006 criteria had higher odds of adverse clinical outcomes. Future research is needed to prospectively evaluate existing diagnostic schemes and develop new risk models for this complex disease.
AB - Background: Multiple cardiac sarcoidosis (CS) diagnostic schemes have been published. Objectives: This study aims to evaluate the association of different CS diagnostic schemes with adverse outcomes. The diagnostic schemes evaluated were 1993, 2006, and 2017 Japanese criteria and the 2014 Heart Rhythm Society criteria. Methods: Data were collected from the Cardiac Sarcoidosis Consortium, an international registry of CS patients. Outcome events were any of the following: all-cause mortality, left ventricular assist device placement, heart transplantation, and appropriate implantable cardioverter-defibrillator therapy. Logistic regression analysis evaluated the association of outcomes with each CS diagnostic scheme. Results: A total of 587 subjects met the following criteria: 1993 Japanese (n = 310, 52.8%), 2006 Japanese (n = 312, 53.2%), 2014 Heart Rhythm Society (n = 480, 81.8%), and 2017 Japanese (n = 112, 19.1%). Patients who met the 1993 criteria were more likely to experience an event than patients who did not (n = 109 of 310, 35.2% vs n = 59 of 277, 21.3%; OR: 2.00; 95% CI: 1.38-2.90; P < 0.001). Similarly, patients who met the 2006 criteria were more likely to have an event than patients who did not (n = 116 of 312, 37.2% vs n = 52 of 275, 18.9%; OR: 2.54; 95% CI: 1.74-3.71; P < 0.001). There was no statistically significant association between the occurrence of an event and whether a patient met the 2014 or the 2017 criteria (OR: 1.39; 95% CI: 0.85-2.27; P = 0.18 or OR: 1.51; 95% CI: 0.97-2.33; P = 0.067, respectively). Conclusions: CS patients who met the 1993 and the 2006 criteria had higher odds of adverse clinical outcomes. Future research is needed to prospectively evaluate existing diagnostic schemes and develop new risk models for this complex disease.
KW - cardiac sarcoidosis
KW - cardiac sarcoidosis consortium
KW - diagnostic criteria
KW - risk assessment
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U2 - 10.1016/j.jacep.2023.04.010
DO - 10.1016/j.jacep.2023.04.010
M3 - Article
C2 - 37227359
AN - SCOPUS:85168154984
SN - 2405-500X
VL - 9
SP - 1719
EP - 1729
JO - JACC: Clinical Electrophysiology
JF - JACC: Clinical Electrophysiology
IS - 8
ER -