Purpose: Pancreatitis-an inflammation of pancreas-is a severe and costly disease. Although many risk factors for pancreatitis are known, many pancreatitis cases, especially in elderly women, are of unknown etiology. Methods: Risk factors for acute pancreatitis (AP) and chronic pancreatitis (CP) were assessed in a prospective cohort (n=36,436 women, aged≥65years). Exposures were self-reported at baseline. Pancreatitis was ascertained by linkage to Medicare claims (1986-2004) categorized by a physician as follows: "AP", one AP episode (n=511) or "CP", 2+ AP or 1+ CP episodes (n=149). Results: Multivariable odds ratios (ORs) and 95% confidence intervals for AP and CP were calculated using multinomial logistic regression. Alcohol use was not associated with AP or CP. Heavy smoking (40+ vs. 0 pack-years) was associated with a twofold increased OR for CP. For body mass index greater than or equal to 30 versus less than 25kg/m2, the ORs were 1.35 (1.07-1.70) for AP (P trend=009) and 0.59 (0.37-0.94) for CP (P trend=01). ORs for AP and CP were increased for hormone replacement therapy use, heart disease, and hypertension. There were positive significant associations between protein and total fat intake for CP and AP. Conclusions: We identified factors associated with AP and CP that may be specific to older women.
Bibliographical noteFunding Information:
This study was supported by National Institutes of Health (NIH) Grant R01CA039742 . A.E.P. was supported by the National Center for Advancing Translational Sciences of the NIH Award Number UL1 TR000114. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors are thankful to Bill Baker and Dr. Cindy Blair for help with the analysis.
© 2015 Elsevier Inc.