Risk factors for intracerebral hemorrhage in a pooled prospective study

Jared D. Sturgeon, Aaron R. Folsom, W. T. Longstreth, Eyal Shahar, Wayne D. Rosamond, Mary Cushman

Research output: Contribution to journalArticlepeer-review

273 Scopus citations


BACKGROUND AND PURPOSE - Few prospective studies have reported risk factors for intracerebral hemorrhage (ICH), and results are inconsistent. We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS). METHODS - The ARIC cohort was recruited in 1987 to 1989 and involves 15 792 men and women, aged 45 to 64 years at baseline, sampled from 4 US communities. The CHS cohort was recruited in 1989 to 1993 and involves 5888 men and women, aged 65 or over at baseline, sampled from 4 US communities. Baseline measurements included many potential vascular risk factors. The cohorts were followed for incident stroke events. RESULTS - Over 263 489 person-years of follow-up, 135 incident ICH events occurred. In a multivariable model, age, African-American ethnicity (versus Whites), and hypertension were positively associated with incident ICH, whereas low-density lipoprotein cholesterol and triglycerides were inversely related to incident ICH. Participants with systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110 mm Hg had 5.55 (95% CI 3.07 to 10.0) times the rate of ICH as nonhypertensives. Sex, smoking, alcohol intake, body mass index, waist-to-hip ratio, waist circumference, and diabetes were not related to ICH. CONCLUSIONS - In this pooled cohort the risk factors for ICH were older age, African-American ethnicity, hypertension, lower LDL-C, and lower triglycerides.

Original languageEnglish (US)
Pages (from-to)2718-2725
Number of pages8
Issue number10
StatePublished - Oct 2007


  • Cerebral hemorrhage
  • Epidemiology
  • Hypertension
  • Risk factors
  • Stroke


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