Risk factors for development of Canine and Human Osteosarcoma: A comparative review

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Osteosarcoma is the most common primary tumor of bone. Osteosarcomas are rare in humans, but occur more commonly in dogs. A comparative approach to studying osteosarcoma has highlighted many clinical and biologic aspects of the disease that are similar between dogs and humans; however, important species-specific differences are becoming increasingly recognized. In this review, we describe risk factors for the development of osteosarcoma in dogs and humans, including height and body size, genetics, and conditions that increase turnover of bone-forming cells, underscoring the concept that stochastic mutational events associated with cellular replication are likely to be the major molecular drivers of this disease. We also discuss adaptive, cancer-protective traits that have evolved in large, long-lived mammals, and how increasing size and longevity in the absence of natural selection can account for the elevated bone cancer risk in modern domestic dogs.

Original languageEnglish (US)
Article number48
JournalVeterinary Sciences
Volume6
Issue number2
DOIs
StatePublished - Jun 1 2019

Keywords

  • Bone cancer
  • Comparative oncology
  • Dog
  • Genetics
  • Human
  • Osteosarcoma
  • Pediatric
  • Risk factors

PubMed: MeSH publication types

  • Journal Article
  • Review

Fingerprint Dive into the research topics of 'Risk factors for development of Canine and Human Osteosarcoma: A comparative review'. Together they form a unique fingerprint.

  • Cite this