Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals

Joseph P. Greene, Sandra L. Lefebvre, Mansen Wang, Mingyin Yang, Elizabeth M. Lund, David J. Polzin

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Objective-To identify risk factors associated with diagnosis of chronic kidney disease (CKD) in cats. Design-Retrospective case-control study. Animals-1,230 cats with a clinical diagnosis of CKD, serum creatinine concentration > 1.6 mg/dL, and urine specific gravity < 1.035 and 1,230 age-matched control cats. Procedures-Data on putative risk factors for CKD were extracted for multivariate logistic regression analysis from the medical records of cats brought to 755 primary care veterinary hospitals. For a subset of cats evaluated 6 to 12 months prior to the date of CKD diagnosis or control group inclusion, the percentage change in body weight between those dates as well as clinical signs at the earlier date were analyzed for associations with CKD development. Results-Risk factors for CKD in cats included thin body condition, prior periodontal disease or cystitis, anesthesia or documented dehydration in the preceding year, being a neutered male (vs spayed female), and living anywhere in the United States other than the northeast. The probability of CKD decreased with increasing body weight in nondehydrated cats, domestic shorthair breed, and prior diagnosis of diabetes mellitus and increased when vomiting, polyuria or polydipsia, appetite or energy loss, or halitosis was present at the time of diagnosis or control group inclusion but not when those signs were reported 6 to 12 months earlier. Median weight loss during the preceding 6 to 12 months was 10.8% and 2.1% in cats with and without CKD, respectively. Conclusions and Clinical Relevance-The probability of CKD diagnosis in cats was influenced by several variables; recent weight loss, particularly in combination with the other factors, warrants assessment of cats for CKD.

Original languageEnglish (US)
Pages (from-to)320-327
Number of pages8
JournalJournal of the American Veterinary Medical Association
Volume244
Issue number3
DOIs
StatePublished - Feb 1 2014

Fingerprint Dive into the research topics of 'Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals'. Together they form a unique fingerprint.

  • Cite this