Risk factors associated with surgical site infection and the development of short-term complications in macaques undergoing indwelling vascular access port placement

Melanie L Graham, E. F. Rieke, M. Wijkstrom, M. Dunning, T. C. Aasheim, M. J. Graczyk, K. J. Pilon, Bernhard J Hering

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Risk factors associated with surgical site infection (SSI) and the development of short-term complications in macaques undergoing vascular access port (VAP) placement are evaluated in this study. Methods: Records from 80 macaques with VAPs were retrospectively reviewed. Logistic regression was used to identify factors associated with short-term post-operative complications. Results: The primary outcome was SSI, which occurred in 21.6% (52.6% in the first 12months vs. 13% thereafter) of procedures. SSI was associated with major secondary complications including VAP removal (11.4%), wound dehiscence (5.7%), and mechanical catheter occlusion (5.7%). In multivariate modeling, only surgical program progress was a statistically significant predictor of SSI, while animal compliance had a slightly protective effect. Conclusions: Vascular access ports have a moderate risk of complications, provided the surgical program optimizes best practices. Under complex experimental conditions, VAPs represent an important refinement, both improving animals'overall well-being and environment and reducing stress.

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalJournal of Medical Primatology
Volume37
Issue number4
DOIs
StatePublished - Aug 1 2008

Keywords

  • Adverse events
  • Central venous catheterization
  • Indwelling catheter
  • Infections
  • Macaca
  • Refinement

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