Risk factors and prevention of dabigatran-related gastrointestinal bleeding in patients with atrial fibrillation

Teerapat Nantsupawat, Suthipong Soontrapa, Nopakoon Nantsupawat, David Sotello, Saranapoom Klomjit, Selcuk Adabag, Alejandro Perez-Verdia

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Introduction: Dabigatran, as compared with warfarin, was associated with lower rates of stroke and systemic embolism with similar rates of major hemorrhage. But it has a significantly higher risk of gastrointestinal bleeding (GIB). There are limited data on how to prevent GIB from dabigatran and what are the risk factors. Methods: We performed a retrospective cohort study of patients with atrial fibrillation who have ever taken dabigatran for thromboprophylaxis from October 2010 to February 2013. Results: A total of 247 patients were identified. There were 10 (4%) patients who developed GIB (6 (6.5%) in PPI/H2RA users vs 4 (2.6%) in non-PPI/H2RA users; P =.184). History of GIB within 1 year prior to dabigatran initiation and HAS-BLED score ≥3 are independent risk factors for GIB, with odds ratio of 25.14 (95% CI, 2.85-221.47; P <.01) and 5.85 (95% CI, 1.31-26.15; P =.021), respectively. Conclusion: In this real-world cohort, PPI/H2RA use was not associated with reduced GIB events. HAS-BLED score ≥3 and prior history of GIB within 1 year are independent risk factors for GIB among dabigatran users.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalJournal of Arrhythmia
Volume34
Issue number1
DOIs
StatePublished - Feb 1 2018

Keywords

  • Atrial fibrillation
  • Dabigatran
  • Gastrointestinal bleeding
  • HAS-BLED

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