Risk factors and impact of non-Aspergillus mold infections following allogeneic HCT: A CIBMTR infection and immune reconstitution analysis

M. L. Riches, S. Trifilio, M. Chen, K. W. Ahn, A. Langston, H. M. Lazarus, D. I. Marks, R. Martino, R. T. Maziarz, G. A. Papanicolou, J. R. Wingard, J. A H Young, C. L. Bennett

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Risk factors for non-Aspergillus mold infection (NAMI) and the impact on transplant outcome are poorly assessed in the current era of antifungal agents. Outcomes of 124 patients receiving allogeneic hematopoietic cell transplantation (HCT) diagnosed with either mucormycosis (n=72) or fusariosis (n=52) between days 0 and 365 after HCT are described and compared with a control cohort (n=11 856). Patients with NAMI had more advanced disease (mucormycois: 25%, fusariosis: 23% and controls: 18%; P=0.004) and were more likely to have a Karnofsky performance status (KPS) <90% at HCT (mucormycosis: 42%, fusariosis: 38% and controls: 28%; P=0.048). The 1-year survival after HCT was 22% (15-29%) for cases and was significantly inferior compared with controls (65% (64-65%); P<0.001). Survival from infection was similarly dismal regardless of mucormycosis: 15% (8-25%) and fusariosis: 21% (11-33%). In multivariable analysis, NAMI was associated with a sixfold higher risk of death (P<0.0001) regardless of the site or timing of infection. Risk factors for mucormycosis include preceding acute GvHD, prior Aspergillus infection and older age. For fusariosis, increased risks including receipt of cord blood, prior CMV infection and transplant before May 2002. In conclusion, NAMI occurs infrequently, is associated with high mortality and appears with similar frequency in the current antifungal era.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalBone marrow transplantation
Volume51
Issue number2
DOIs
StatePublished - Feb 1 2016

Bibliographical note

Funding Information:
The CIBMTR is supported by Public Health Service Grant/Cooperative Agreement U24-CA076518 from the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID); a Grant/Cooperative Agreement 5U10HL069294 from NHLBI and NCI; a contract HHSH250201200016C with Health Resources and Services Administration (HRSA/DHHS); two grants N00014-13-1-0039 and N00014-14-1-0028 from the Office of Naval Research; and grants from ∗Actinium Pharmaceuticals, Allos Therapeutics, Inc., ∗Amgen, Inc., anonymous donation to the Medical College of Wisconsin, Ariad, Be the Match Foundation, ∗Blue Cross and Blue Shield Association, ∗Celgene Corporation, Chimerix, Inc., Fred Hutchinson Cancer Research Center, Fresenius- Biotech North America, Inc., ∗Gamida Cell Teva Joint Venture Ltd., Genentech, Inc., ∗Gentium SpA, Genzyme Corporation, GlaxoSmithKline, Health Research, Inc., Roswell Park Cancer Institute, HistoGenetics, Inc., Incyte Corporation, Jeff Gordon Children’s Foundation, Kiadis Pharma, The Leukemia &amp; Lymphoma Society, Medac GmbH, The Medical College of Wisconsin, Merck &amp; Co, Inc., Millennium: The Takeda Oncology Co., ∗Milliman USA, Inc., ∗Miltenyi Biotec, Inc., National Marrow Donor Program, Onyx Pharmaceuticals, Optum Healthcare Solutions, Inc., Osiris Therapeutics, Inc., Otsuka America Pharmaceutical, Inc., Perkin Elmer, Inc., ∗Remedy Informatics, ∗Sanofi US, Seattle Genetics, Sigma-Tau Pharmaceuticals, Soligenix, Inc., St Baldrick’s Foundation, StemCyte, A Global Cord Blood Therapeutics Co., Stemsoft Software, Inc., Swedish Orphan Biovitrum, ∗Tarix Pharmaceuticals, ∗TerumoBCT, ∗Teva Neuroscience, Inc., ∗THERAKOS, Inc., University of Minnesota, University of Utah and ∗Wellpoint, Inc. ∗These are the Corporate Members.

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