Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011

The National Birth Defects Prevention Study

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Purpose To compare the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or opioids to the use of acetaminophen without NSAIDs or opioids with respect to associations with birth defects. Methods We used data from the National Birth Defects Prevention Study (1997–2011). Exposure was self-reported maternal analgesic use from the month before through the third month of pregnancy (periconceptional). Adjusted odds ratios (aORs) were calculated to examine associations with 16 birth defects. Results Compared to acetaminophen, mothers reporting NSAIDs were significantly more likely to have offspring with gastroschisis, hypospadias, cleft palate, cleft lip with cleft palate, cleft lip without cleft palate, anencephaly, spina bifida, hypoplastic left heart syndrome, pulmonary valve stenosis, and tetralogy of Fallot (aOR range, 1.2–1.6). Opioids were associated with tetralogy of Fallot, perimembranous ventricular septal defect, and ventricular septal defect with atrial septal defect (aOR range, 1.8–2.3), whereas use of both opioids and NSAIDs was associated with gastroschisis, cleft palate, spina bifida, hypoplastic left heart syndrome, and pulmonary valve stenosis (aOR range, 2.0–2.9). Conclusions Compared to periconceptional use of acetaminophen, selected birth defects occurred more frequently among infants of women using NSAIDs and/or opioids. However, we could not definitely determine whether these risks relate to the drugs or to indications for treatment.

Original languageEnglish (US)
Pages (from-to)645-653.e2
JournalAnnals of epidemiology
Volume27
Issue number10
DOIs
StatePublished - Oct 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017

Keywords

  • Acetaminophen
  • Analgesics
  • Analgesics
  • Anti-inflammatory agents
  • Congenital abnormalities
  • Nonsteroidal
  • Opioids
  • Pregnancy
  • Teratogens

Fingerprint

Dive into the research topics of 'Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study 1997–2011'. Together they form a unique fingerprint.

Cite this