A recent Cell paper identifies a novel population of neurons within the ventral tegmental area producing the endogenous opioid nociceptin that regulates dopamine neuron firing and acts uniquely to gate motivation in reward seeking. These results highlight neuropeptidergic signaling as a critical component of functional heterogeneity in the midbrain.
Bibliographical notePublisher Copyright:
© 2019 Elsevier Inc.
- fiber photometry
- ventral tegmental area