Abstract
The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was based on the Threshold of Toxicological Concern (TTC) of 0.03 mg/kg/day for a Cramer Class I material. The estimated systemic exposure is determined to be below this value while assuming 80% absorption from skin contact and 100% from inhalation. A systemic exposure below the TTC value is acceptable.
Original language | English (US) |
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Pages (from-to) | S76-S87 |
Journal | Food and Chemical Toxicology |
Volume | 84 |
DOIs | |
State | Published - Jul 23 2015 |
Bibliographical note
Publisher Copyright:© 2015 Elsevier Ltd.
Keywords
- Developmental and reproductive toxicity
- Environmental safety
- Genotoxicity
- Local respiratory toxicity
- Phototoxicity/photoallergenicity
- Repeated dose
- Skin sensitization