RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; Y. Miyachi; V. T. Politano; G. Ritacco; D. Salvito; T. W. Schultz; J. Shen; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2015.12.014

RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Original language	English (US)
Pages (from-to)	S11-S24
Journal	Food and Chemical Toxicology
Volume	97
DOIs	https://doi.org/10.1016/j.fct.2015.12.014
State	Published - Nov 1 2016

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd

Keywords

Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity and photoallergenicity
Repeated dose
Skin sensitization
developmental and reproductive toxicity

Publisher link

10.1016/j.fct.2015.12.014

Find It

Find It at U of M Libraries

Cite this

Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., ... Wilcox, D. K. (2016). RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0. Food and Chemical Toxicology, 97, S11-S24. https://doi.org/10.1016/j.fct.2015.12.014

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0', Food and Chemical Toxicology, vol. 97, pp. S11-S24. https://doi.org/10.1016/j.fct.2015.12.014

@article{f44da4cbccd24384bbaef32908374fbe,

title = "RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0",

abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.",

keywords = "Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity and photoallergenicity, Repeated dose, Skin sensitization, developmental and reproductive toxicity",

author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Y. Miyachi and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd",

year = "2016",

month = nov,

day = "1",

doi = "10.1016/j.fct.2015.12.014",

language = "English (US)",

volume = "97",

pages = "S11--S24",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Miyachi, Y.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity and photoallergenicity

KW - Repeated dose

KW - Skin sensitization

KW - developmental and reproductive toxicity

UR - http://www.scopus.com/inward/record.url?scp=84954215403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954215403&partnerID=8YFLogxK

U2 - 10.1016/j.fct.2015.12.014

DO - 10.1016/j.fct.2015.12.014

M3 - Short survey

C2 - 26702985

AN - SCOPUS:84954215403

SN - 0278-6915

VL - 97

SP - S11-S24

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, l-linalool, CAS Registry Number 126-91-0

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this