RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, R. Parakhia, T. M. Penning, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. ShenI. G. Sipes, B. Wall, D. K. Wilcox

    Research output: Contribution to journalShort survey

    Abstract

    This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    Original languageEnglish (US)
    Pages (from-to)S1-S8
    JournalFood and Chemical Toxicology
    Volume110
    DOIs
    StatePublished - Dec 1 2017

    Fingerprint

    Phototoxic Dermatitis
    Fragrances
    safety assessment
    endpoints
    Toxicity
    Registries
    ingredients
    odors
    phototoxicity
    Safety
    Skin
    toxicity
    Toxicology
    reproductive toxicology
    developmental toxicity
    genotoxicity
    dosage
    acetates
    pichtosin

    Keywords

    • Developmental and reproductive toxicity
    • Environmental safety
    • Genotoxicity
    • Local respiratory toxicity
    • Phototoxicity/photoallergenicity
    • Repeated dose
    • Skin sensitization

    Cite this

    RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L.; La Cava, S.; Lapczynski, A.; Liebler, D. C.; O'Brien, D.; Parakhia, R.; Penning, T. M.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

    In: Food and Chemical Toxicology, Vol. 110, 01.12.2017, p. S1-S8.

    Research output: Contribution to journalShort survey

    Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lapczynski, A, Liebler, DC, O'Brien, D, Parakhia, R, Penning, TM, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2017, 'RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9', Food and Chemical Toxicology, vol. 110, pp. S1-S8. https://doi.org/10.1016/j.fct.2016.10.029
    Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Kromidas, L. ; La Cava, S. ; Lapczynski, A. ; Liebler, D. C. ; O'Brien, D. ; Parakhia, R. ; Penning, T. M. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9. In: Food and Chemical Toxicology. 2017 ; Vol. 110. pp. S1-S8.
    @article{e61c8f38b5d14297b81844ba2a201d02,
    title = "RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9",
    abstract = "This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.",
    keywords = "Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization",
    author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and A. Lapczynski and Liebler, {D. C.} and D. O'Brien and R. Parakhia and Penning, {T. M.} and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",
    year = "2017",
    month = "12",
    day = "1",
    doi = "10.1016/j.fct.2016.10.029",
    language = "English (US)",
    volume = "110",
    pages = "S1--S8",
    journal = "Food and Chemical Toxicology",
    issn = "0278-6915",
    publisher = "Elsevier Limited",

    }

    TY - JOUR

    T1 - RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

    AU - Api, A. M.

    AU - Belsito, D.

    AU - Bhatia, S.

    AU - Bruze, M.

    AU - Calow, P.

    AU - Dagli, M. L.

    AU - Dekant, W.

    AU - Fryer, A. D.

    AU - Kromidas, L.

    AU - La Cava, S.

    AU - Lapczynski, A.

    AU - Liebler, D. C.

    AU - O'Brien, D.

    AU - Parakhia, R.

    AU - Penning, T. M.

    AU - Politano, V. T.

    AU - Ritacco, G.

    AU - Salvito, D.

    AU - Schultz, T. W.

    AU - Shen, J.

    AU - Sipes, I. G.

    AU - Wall, B.

    AU - Wilcox, D. K.

    PY - 2017/12/1

    Y1 - 2017/12/1

    N2 - This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    AB - This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    KW - Developmental and reproductive toxicity

    KW - Environmental safety

    KW - Genotoxicity

    KW - Local respiratory toxicity

    KW - Phototoxicity/photoallergenicity

    KW - Repeated dose

    KW - Skin sensitization

    UR - http://www.scopus.com/inward/record.url?scp=85006757043&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85006757043&partnerID=8YFLogxK

    U2 - 10.1016/j.fct.2016.10.029

    DO - 10.1016/j.fct.2016.10.029

    M3 - Short survey

    C2 - 27815161

    AN - SCOPUS:85006757043

    VL - 110

    SP - S1-S8

    JO - Food and Chemical Toxicology

    JF - Food and Chemical Toxicology

    SN - 0278-6915

    ER -