RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, R. Parakhia, T. M. Penning, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. ShenI. G. Sipes, B. Wall, D. K. Wilcox

    Research output: Contribution to journalShort surveypeer-review

    Abstract

    This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    Original languageEnglish (US)
    Pages (from-to)S1-S8
    JournalFood and Chemical Toxicology
    Volume110
    DOIs
    StatePublished - Dec 2017

    Keywords

    • Developmental and reproductive toxicity
    • Environmental safety
    • Genotoxicity
    • Local respiratory toxicity
    • Phototoxicity/photoallergenicity
    • Repeated dose
    • Skin sensitization

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