RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; Y. Miyachi; V. T. Politano; G. Ritacco; D. Salvito; T. W. Schultz; J. Shen; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2015.09.014

RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Original language	English (US)
Pages (from-to)	S110-S121
Journal	Food and Chemical Toxicology
Volume	84
DOIs	https://doi.org/10.1016/j.fct.2015.09.014
State	Published - Jul 23 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose, developmental and reproductive toxicity
Skin sensitization

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10.1016/j.fct.2015.09.014

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7. Food and Chemical Toxicology, 84, S110-S121. https://doi.org/10.1016/j.fct.2015.09.014

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2015, 'RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7', Food and Chemical Toxicology, vol. 84, pp. S110-S121. https://doi.org/10.1016/j.fct.2015.09.014

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abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.",

keywords = "Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, developmental and reproductive toxicity, Skin sensitization",

author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Y. Miyachi and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",

year = "2015",

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doi = "10.1016/j.fct.2015.09.014",

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T1 - RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Miyachi, Y.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2015/7/23

Y1 - 2015/7/23

N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using to have the most conservative systemic exposure derived NOAEL of 47 mg/kg/day. A dietary 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 2350 while considering 10.3% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose, developmental and reproductive toxicity

KW - Skin sensitization

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U2 - 10.1016/j.fct.2015.09.014

DO - 10.1016/j.fct.2015.09.014

M3 - Short survey

C2 - 26419451

AN - SCOPUS:84955402049

SN - 0278-6915

VL - 84

SP - S110-S121

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, isoamyl salicylate, CAS registry number 87-20-7

Abstract

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Keywords

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