RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; Y. Miyachi; V. T. Politano; G. Ritacco; D. Salvito; J. Shen; T. W. Schultz; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2015.08.022

RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1

A. M. Api
, D. Belsito
, S. Bhatia
, M. Bruze
, P. Calow
, M. L. Dagli
, W. Dekant
, A. D. Fryer
, L. Kromidas
, S. La Cava
, J. F. Lalko
, A. Lapczynski
, D. C. Liebler
, Y. Miyachi
, V. T. Politano
, G. Ritacco
, D. Salvito
, J. Shen
, T. W. Schultz
, I. G. Sipes

B. Wall, D. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 15 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 10,714 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

Original language	English (US)
Pages (from-to)	S25-S32
Journal	Food and Chemical Toxicology
Volume	84
DOIs	https://doi.org/10.1016/j.fct.2015.08.022
State	Published - Jul 23 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

Developmental and reproductive toxicity
Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose
Skin sensitization

Publisher link

10.1016/j.fct.2015.08.022

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Shen, J., Schultz, T. W., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1. Food and Chemical Toxicology, 84, S25-S32. https://doi.org/10.1016/j.fct.2015.08.022

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Shen, J, Schultz, TW, Sipes, IG, Wall, B & Wilcox, DK 2015, 'RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1', Food and Chemical Toxicology, vol. 84, pp. S25-S32. https://doi.org/10.1016/j.fct.2015.08.022

@article{06786f9543f1478bb69c801a7e0d65f7,

title = "RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1",

abstract = "The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 15 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 10,714 while assuming 100\% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.",

keywords = "Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization",

author = "Api, \{A. M.\} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, \{M. L.\} and W. Dekant and Fryer, \{A. D.\} and L. Kromidas and \{La Cava\}, S. and Lalko, \{J. F.\} and A. Lapczynski and Liebler, \{D. C.\} and Y. Miyachi and Politano, \{V. T.\} and G. Ritacco and D. Salvito and J. Shen and Schultz, \{T. W.\} and Sipes, \{I. G.\} and B. Wall and Wilcox, \{D. K.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = jul,

day = "23",

doi = "10.1016/j.fct.2015.08.022",

language = "English (US)",

volume = "84",

pages = "S25--S32",

journal = "Food and Chemical Toxicology",

issn = "0278-6915",

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TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Miyachi, Y.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Shen, J.

AU - Schultz, T. W.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2015/7/23

Y1 - 2015/7/23

N2 - The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 15 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 10,714 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 15 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 10,714 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

KW - Developmental and reproductive toxicity

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose

KW - Skin sensitization

UR - https://www.scopus.com/pages/publications/84955335518

UR - https://www.scopus.com/pages/publications/84955335518#tab=citedBy

U2 - 10.1016/j.fct.2015.08.022

DO - 10.1016/j.fct.2015.08.022

M3 - Short survey

C2 - 26342767

AN - SCOPUS:84955335518

SN - 0278-6915

VL - 84

SP - S25-S32

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1

Abstract

Bibliographical note

Keywords

Publisher link

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