RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; Y. Miyachi; V. T. Politano; G. Ritacco; D. Salvito; J. Shen; T. W. Schultz; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2015.07.009

RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, J. Shen, T. W. Schultz, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have the most conservative systemic exposure derived NO[A]EL of 50 mg/kg/day, based on OECD gavage toxicity studies in rats, that resulted in a MOE of 4545455 after considering 100% absorption from skin contact and inhalation. A MOE of > 100 is deemed acceptable.

Original language	English (US)
Pages (from-to)	S50-S56
Journal	Food and Chemical Toxicology
Volume	84
DOIs	https://doi.org/10.1016/j.fct.2015.07.009
State	Published - Jun 22 2015

Keywords

Environmental toxicology
Genotoxicity
Local respiratory toxicology
Phototoxicity/photoallergenicity
Repeated dose toxicity/developmental and reproductive toxicity
Skin sensitization

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10.1016/j.fct.2015.07.009

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Shen, J., Schultz, T. W., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4. Food and Chemical Toxicology, 84, S50-S56. https://doi.org/10.1016/j.fct.2015.07.009

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Shen, J, Schultz, TW, Sipes, IG, Wall, B & Wilcox, DK 2015, 'RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4', Food and Chemical Toxicology, vol. 84, pp. S50-S56. https://doi.org/10.1016/j.fct.2015.07.009

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title = "RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4",

abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have the most conservative systemic exposure derived NO[A]EL of 50 mg/kg/day, based on OECD gavage toxicity studies in rats, that resulted in a MOE of 4545455 after considering 100% absorption from skin contact and inhalation. A MOE of > 100 is deemed acceptable.",

keywords = "Environmental toxicology, Genotoxicity, Local respiratory toxicology, Phototoxicity/photoallergenicity, Repeated dose toxicity/developmental and reproductive toxicity, Skin sensitization",

author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Y. Miyachi and Politano, {V. T.} and G. Ritacco and D. Salvito and J. Shen and Schultz, {T. W.} and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",

year = "2015",

month = jun,

day = "22",

doi = "10.1016/j.fct.2015.07.009",

language = "English (US)",

volume = "84",

pages = "S50--S56",

journal = "Food and Chemical Toxicology",

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TY - JOUR

T1 - RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Miyachi, Y.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Shen, J.

AU - Schultz, T. W.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2015/6/22

Y1 - 2015/6/22

N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have the most conservative systemic exposure derived NO[A]EL of 50 mg/kg/day, based on OECD gavage toxicity studies in rats, that resulted in a MOE of 4545455 after considering 100% absorption from skin contact and inhalation. A MOE of > 100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have the most conservative systemic exposure derived NO[A]EL of 50 mg/kg/day, based on OECD gavage toxicity studies in rats, that resulted in a MOE of 4545455 after considering 100% absorption from skin contact and inhalation. A MOE of > 100 is deemed acceptable.

KW - Environmental toxicology

KW - Genotoxicity

KW - Local respiratory toxicology

KW - Phototoxicity/photoallergenicity

KW - Repeated dose toxicity/developmental and reproductive toxicity

KW - Skin sensitization

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U2 - 10.1016/j.fct.2015.07.009

DO - 10.1016/j.fct.2015.07.009

M3 - Short survey

C2 - 26206495

AN - SCOPUS:84955189830

SN - 0278-6915

VL - 84

SP - S50-S56

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4

Abstract

Keywords

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