RIFM fragrance ingredient safety assessment, 2-methyl-3-buten-2-ol, CAS Registry Number 115-18-4

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, J. Shen, T. W. Schultz, I. G. SipesB. Wall, D. K. Wilcox

    Research output: Contribution to journalShort surveypeer-review

    1 Scopus citations

    Abstract

    The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have the most conservative systemic exposure derived NO[A]EL of 50 mg/kg/day, based on OECD gavage toxicity studies in rats, that resulted in a MOE of 4545455 after considering 100% absorption from skin contact and inhalation. A MOE of > 100 is deemed acceptable.

    Original languageEnglish (US)
    Pages (from-to)S50-S56
    JournalFood and Chemical Toxicology
    Volume84
    DOIs
    StatePublished - Jun 22 2015

    Keywords

    • Environmental toxicology
    • Genotoxicity
    • Local respiratory toxicology
    • Phototoxicity/photoallergenicity
    • Repeated dose toxicity/developmental and reproductive toxicity
    • Skin sensitization

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