RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, T. M. Penning, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes & 2 others B. Wall, D. K. Wilcox

    Research output: Contribution to journalShort survey

    Abstract

    The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog 2-butyloctan-1-ol (CAS # 3913-02-8) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental and repeat dose toxicity endpoints were completed data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    Original languageEnglish (US)
    Pages (from-to)S147-S156
    JournalFood and Chemical Toxicology
    Volume97
    DOIs
    StatePublished - Nov 1 2016

    Fingerprint

    Phototoxic Dermatitis
    Fragrances
    safety assessment
    Toxicity
    Registries
    ingredients
    odors
    endpoints
    Safety
    Skin
    Toxicology
    toxicity
    phototoxicity
    reproductive toxicology
    developmental toxicity
    genotoxicity
    dosage
    hexanols
    2-ethylhexanol

    Keywords

    • Environmental Safety
    • Genotoxicity
    • Local Respiratory Toxicity
    • Phototoxicity/Photoallergenicity
    • Repeated dose, Developmental and Reproductive Toxicity
    • Skin Sensitization

    Cite this

    RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L.; La Cava, S.; Lalko, J. F.; Lapczynski, A.; Liebler, D. C.; Penning, T. M.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

    In: Food and Chemical Toxicology, Vol. 97, 01.11.2016, p. S147-S156.

    Research output: Contribution to journalShort survey

    Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Penning, TM, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7' Food and Chemical Toxicology, vol. 97, pp. S147-S156. https://doi.org/10.1016/j.fct.2016.09.001
    Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Kromidas, L. ; La Cava, S. ; Lalko, J. F. ; Lapczynski, A. ; Liebler, D. C. ; Penning, T. M. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7. In: Food and Chemical Toxicology. 2016 ; Vol. 97. pp. S147-S156.
    @article{33db0122f41c44cbb6d44302ce7e377f,
    title = "RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7",
    abstract = "The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog 2-butyloctan-1-ol (CAS # 3913-02-8) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental and repeat dose toxicity endpoints were completed data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.",
    keywords = "Environmental Safety, Genotoxicity, Local Respiratory Toxicity, Phototoxicity/Photoallergenicity, Repeated dose, Developmental and Reproductive Toxicity, Skin Sensitization",
    author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Penning, {T. M.} and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",
    year = "2016",
    month = "11",
    day = "1",
    doi = "10.1016/j.fct.2016.09.001",
    language = "English (US)",
    volume = "97",
    pages = "S147--S156",
    journal = "Food and Chemical Toxicology",
    issn = "0278-6915",
    publisher = "Elsevier Limited",

    }

    TY - JOUR

    T1 - RIFM fragrance ingredient safety assessment, 2-ethyl-1-hexanol, CAS registry number 104-76-7

    AU - Api, A. M.

    AU - Belsito, D.

    AU - Bhatia, S.

    AU - Bruze, M.

    AU - Calow, P.

    AU - Dagli, M. L.

    AU - Dekant, W.

    AU - Fryer, A. D.

    AU - Kromidas, L.

    AU - La Cava, S.

    AU - Lalko, J. F.

    AU - Lapczynski, A.

    AU - Liebler, D. C.

    AU - Penning, T. M.

    AU - Politano, V. T.

    AU - Ritacco, G.

    AU - Salvito, D.

    AU - Schultz, T. W.

    AU - Shen, J.

    AU - Sipes, I. G.

    AU - Wall, B.

    AU - Wilcox, D. K.

    PY - 2016/11/1

    Y1 - 2016/11/1

    N2 - The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog 2-butyloctan-1-ol (CAS # 3913-02-8) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental and repeat dose toxicity endpoints were completed data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    AB - The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog 2-butyloctan-1-ol (CAS # 3913-02-8) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental and repeat dose toxicity endpoints were completed data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    KW - Environmental Safety

    KW - Genotoxicity

    KW - Local Respiratory Toxicity

    KW - Phototoxicity/Photoallergenicity

    KW - Repeated dose, Developmental and Reproductive Toxicity

    KW - Skin Sensitization

    UR - http://www.scopus.com/inward/record.url?scp=84994761926&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84994761926&partnerID=8YFLogxK

    U2 - 10.1016/j.fct.2016.09.001

    DO - 10.1016/j.fct.2016.09.001

    M3 - Short survey

    VL - 97

    SP - S147-S156

    JO - Food and Chemical Toxicology

    JF - Food and Chemical Toxicology

    SN - 0278-6915

    ER -