RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes & 2 others B. Wall, D. K. Wilcox

    Research output: Contribution to journalShort survey

    Abstract

    The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    Original languageEnglish (US)
    Pages (from-to)S157-S167
    JournalFood and Chemical Toxicology
    Volume97
    DOIs
    StatePublished - Nov 1 2016

    Fingerprint

    Phototoxic Dermatitis
    Fragrances
    safety assessment
    butanol
    endpoints
    Toxicity
    Registries
    ingredients
    Heptanol
    odors
    Safety
    Skin
    2-Propanol
    reproductive toxicology
    toxicity
    developmental toxicity
    phototoxicity
    Toxicology
    Hexanols
    isopropyl alcohol

    Keywords

    • Developmental and reproductive
    • Environmental safety
    • Genotoxicity
    • Local respiratory toxicity
    • Phototoxicity/photoallergenicity
    • Repeated dose
    • Skin sensitization
    • Toxicity

    Cite this

    RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L.; La Cava, S.; Lalko, J. F.; Lapczynski, A.; Liebler, D. C.; Miyachi, Y.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

    In: Food and Chemical Toxicology, Vol. 97, 01.11.2016, p. S157-S167.

    Research output: Contribution to journalShort survey

    Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0', Food and Chemical Toxicology, vol. 97, pp. S157-S167. https://doi.org/10.1016/j.fct.2016.09.022
    Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Kromidas, L. ; La Cava, S. ; Lalko, J. F. ; Lapczynski, A. ; Liebler, D. C. ; Miyachi, Y. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0. In: Food and Chemical Toxicology. 2016 ; Vol. 97. pp. S157-S167.
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    abstract = "The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.",
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    T1 - RIFM fragrance ingredient safety assessment, 2-ethyl-1-butanol, CAS Registry Number 97-95-0

    AU - Api, A. M.

    AU - Belsito, D.

    AU - Bhatia, S.

    AU - Bruze, M.

    AU - Calow, P.

    AU - Dagli, M. L.

    AU - Dekant, W.

    AU - Fryer, A. D.

    AU - Kromidas, L.

    AU - La Cava, S.

    AU - Lalko, J. F.

    AU - Lapczynski, A.

    AU - Liebler, D. C.

    AU - Miyachi, Y.

    AU - Politano, V. T.

    AU - Ritacco, G.

    AU - Salvito, D.

    AU - Schultz, T. W.

    AU - Shen, J.

    AU - Sipes, I. G.

    AU - Wall, B.

    AU - Wilcox, D. K.

    PY - 2016/11/1

    Y1 - 2016/11/1

    N2 - The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

    AB - The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

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    KW - Local respiratory toxicity

    KW - Phototoxicity/photoallergenicity

    KW - Repeated dose

    KW - Skin sensitization

    KW - Toxicity

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