RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes & 2 others B. Wall, D. K. Wilcox

    Research output: Contribution to journalShort survey

    Abstract

    The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.

    Original languageEnglish (US)
    Pages (from-to)S101-S109
    JournalFood and Chemical Toxicology
    Volume97
    DOIs
    StatePublished - Nov 1 2016

    Fingerprint

    Phototoxic Dermatitis
    Fragrances
    safety assessment
    Registries
    ingredients
    odors
    Safety
    Toxicity
    Skin
    Toxicology
    endpoints
    developmental toxicity
    phototoxicity
    toxicity
    reproductive toxicology
    genotoxicity
    dosage
    acetyl methyl tetramethyl tetralin

    Keywords

    • Developmental and reproductive toxicity
    • Environmental safety
    • Genotoxicity
    • Local respiratory toxicity
    • Phototoxicity/photoallergenicity
    • Repeated dose
    • Skin sensitization

    Cite this

    RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L.; La Cava, S.; Lalko, J. F.; Lapczynski, A.; Liebler, D. C.; Miyachi, Y.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

    In: Food and Chemical Toxicology, Vol. 97, 01.11.2016, p. S101-S109.

    Research output: Contribution to journalShort survey

    Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8' Food and Chemical Toxicology, vol. 97, pp. S101-S109. https://doi.org/10.1016/j.fct.2016.07.031
    Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, A. D. ; Kromidas, L. ; La Cava, S. ; Lalko, J. F. ; Lapczynski, A. ; Liebler, D. C. ; Miyachi, Y. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8. In: Food and Chemical Toxicology. 2016 ; Vol. 97. pp. S101-S109.
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    abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.",
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    AU - Api, A. M.

    AU - Belsito, D.

    AU - Bhatia, S.

    AU - Bruze, M.

    AU - Calow, P.

    AU - Dagli, M. L.

    AU - Dekant, W.

    AU - Fryer, A. D.

    AU - Kromidas, L.

    AU - La Cava, S.

    AU - Lalko, J. F.

    AU - Lapczynski, A.

    AU - Liebler, D. C.

    AU - Miyachi, Y.

    AU - Politano, V. T.

    AU - Ritacco, G.

    AU - Salvito, D.

    AU - Schultz, T. W.

    AU - Shen, J.

    AU - Sipes, I. G.

    AU - Wall, B.

    AU - Wilcox, D. K.

    PY - 2016/11/1

    Y1 - 2016/11/1

    N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.

    AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.

    KW - Developmental and reproductive toxicity

    KW - Environmental safety

    KW - Genotoxicity

    KW - Local respiratory toxicity

    KW - Phototoxicity/photoallergenicity

    KW - Repeated dose

    KW - Skin sensitization

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