Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S101-S109 |
| Journal | Food and Chemical Toxicology |
| Volume | 97 |
| DOIs | |
| State | Published - Nov 1 2016 |
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Keywords
- Developmental and reproductive toxicity
- Environmental safety
- Genotoxicity
- Local respiratory toxicity
- Phototoxicity/photoallergenicity
- Repeated dose
- Skin sensitization
Cite this
RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, A. D.; Kromidas, L.; La Cava, S.; Lalko, J. F.; Lapczynski, A.; Liebler, D. C.; Miyachi, Y.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.
In: Food and Chemical Toxicology, Vol. 97, 01.11.2016, p. S101-S109.Research output: Contribution to journal › Short survey
}
TY - JOUR
T1 - RIFM fragrance ingredient safety assessment, 1-(1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthyl)propan-1-one, CAS Registry Number 74499-60-8
AU - Api, A. M.
AU - Belsito, D.
AU - Bhatia, S.
AU - Bruze, M.
AU - Calow, P.
AU - Dagli, M. L.
AU - Dekant, W.
AU - Fryer, A. D.
AU - Kromidas, L.
AU - La Cava, S.
AU - Lalko, J. F.
AU - Lapczynski, A.
AU - Liebler, D. C.
AU - Miyachi, Y.
AU - Politano, V. T.
AU - Ritacco, G.
AU - Salvito, D.
AU - Schultz, T. W.
AU - Shen, J.
AU - Sipes, I. G.
AU - Wall, B.
AU - Wilcox, D. K.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.
AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the target material and the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) show that this material is not genotoxic. Data from the suitable read across analog 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (CAS # 21145-77-7) provided a MOE > 100 for the repeat dose and developmental toxicity endpoints. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class II material (0.009 mg/kg/day and 0.47 mg/day, respectively). Data on the target material showed that this material is below the non-reactive DST for skin sensitization and did not have the potential for phototoxicity or photoallergenicity. The environmental endpoint was completed as described in the RIFM Framework.
KW - Developmental and reproductive toxicity
KW - Environmental safety
KW - Genotoxicity
KW - Local respiratory toxicity
KW - Phototoxicity/photoallergenicity
KW - Repeated dose
KW - Skin sensitization
UR - http://www.scopus.com/inward/record.url?scp=84997272193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84997272193&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2016.07.031
DO - 10.1016/j.fct.2016.07.031
M3 - Short survey
C2 - 27475045
AN - SCOPUS:84997272193
VL - 97
SP - S101-S109
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
ER -