RIFM fragrance ingredient safety assessment, α-Methylbenzyl acetate, CAS Registry Number 93-92-5

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. WallD. K. Wilcox

    Research output: Contribution to journalShort surveypeer-review

    Abstract

    The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Developmental toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 100 mg/kg/day. A gavage developmental toxicity study conducted in rats on a suitable read across analog resulted in aMOE of 3571 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

    Original languageEnglish (US)
    Pages (from-to)S57-S68
    JournalFood and Chemical Toxicology
    Volume97
    DOIs
    StatePublished - Nov 1 2016

    Keywords

    • Environmental safety
    • Genotoxicity
    • Local respiratory toxicity
    • Phototoxicity/photoallergenicity
    • Repeated dose
    • Reproductive and developmental toxicity
    • Skin sensitization

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