RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; V. T. Politano; G. Ritacco; D. Salvito; T. W. Schultz; J. Shen; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2015.09.006

RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. WallD. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 29.9 mg/kg/day. A dietary 14-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 3784810 while considering 9.54% absorption from skin contact and 100% from inhalation. A MOE of > 100 is deemed acceptable.

Original language	English (US)
Pages (from-to)	S100-S109
Journal	Food and Chemical Toxicology
Volume	84
DOIs	https://doi.org/10.1016/j.fct.2015.09.006
State	Published - Jul 23 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose, developmental and reproductive toxicity
Skin sensitization

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10.1016/j.fct.2015.09.006

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., Sipes, I. G., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6. Food and Chemical Toxicology, 84, S100-S109. https://doi.org/10.1016/j.fct.2015.09.006

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2015, 'RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6', Food and Chemical Toxicology, vol. 84, pp. S100-S109. https://doi.org/10.1016/j.fct.2015.09.006

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title = "RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6",

abstract = "The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 29.9 mg/kg/day. A dietary 14-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 3784810 while considering 9.54% absorption from skin contact and 100% from inhalation. A MOE of > 100 is deemed acceptable.",

keywords = "Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, developmental and reproductive toxicity, Skin sensitization",

author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = jul,

day = "23",

doi = "10.1016/j.fct.2015.09.006",

language = "English (US)",

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T1 - RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2015/7/23

Y1 - 2015/7/23

N2 - The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 29.9 mg/kg/day. A dietary 14-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 3784810 while considering 9.54% absorption from skin contact and 100% from inhalation. A MOE of > 100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 29.9 mg/kg/day. A dietary 14-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 3784810 while considering 9.54% absorption from skin contact and 100% from inhalation. A MOE of > 100 is deemed acceptable.

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose, developmental and reproductive toxicity

KW - Skin sensitization

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U2 - 10.1016/j.fct.2015.09.006

DO - 10.1016/j.fct.2015.09.006

M3 - Short survey

C2 - 26364876

AN - SCOPUS:84955400170

SN - 0278-6915

VL - 84

SP - S100-S109

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6

Abstract

Bibliographical note

Keywords

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