RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. WallD. K. Wilcox

    Research output: Contribution to journalShort survey

    1 Scopus citations

    Abstract

    The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 29.9 mg/kg/day. A dietary 14-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 3784810 while considering 9.54% absorption from skin contact and 100% from inhalation. A MOE of > 100 is deemed acceptable.

    Original languageEnglish (US)
    Pages (from-to)S100-S109
    JournalFood and Chemical Toxicology
    Volume84
    DOIs
    StatePublished - Jul 23 2015

    Keywords

    • Environmental safety
    • Genotoxicity
    • Local respiratory toxicity
    • Phototoxicity/photoallergenicity
    • Repeated dose, developmental and reproductive toxicity
    • Skin sensitization

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    Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., Sipes, I. G., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, α-butylcinnamaldehyde, CAS Registry Number 7492-44-6. Food and Chemical Toxicology, 84, S100-S109. https://doi.org/10.1016/j.fct.2015.09.006