Rich club analysis of structural brain connectivity at 7 tesla versus 3 tesla

Emily L. Dennis; Liang Zhan; Neda Jahanshad; Bryon A. Mueller; Yan Jin; Christophe Lenglet; Essa Yacoub; Guillermo Sapiro; Kamil Ugurbil; Noam Harel; Arthurw Toga; Kelvin O. Lim; Paul M. Thompson

doi:10.1007/978-3-319-02475-2_19

Rich club analysis of structural brain connectivity at 7 tesla versus 3 tesla

Emily L. Dennis, Liang Zhan, Neda Jahanshad, Bryon A. Mueller, Yan Jin, Christophe Lenglet, Essa Yacoub, Guillermo Sapiro, Kamil Ugurbil, Noam Harel, Arthurw Toga, Kelvin O. Lim, Paul M. Thompson

Research output: Contribution to journal › Conference article › peer-review

3 Scopus citations

Abstract

The ‘rich club’ is a relatively new concept in brain connectivity analysis, which identifies a core of densely interconnected high-degree nodes. Establishing normative measures for rich club organization is vital, as is understanding how scanning parameters affect it.We compared the rich club organization in 23 subjects scanned at both 7 and 3 T, with 128-gradient high angular resolution diffusion imaging (HARDI). The rich club coefficient (RCC) did not differ significantly between low and high field scans, but the field strength did affect which nodes were included in the rich club. We also examined 3 subjects with Alzheimer’s disease and 3 healthy elderly controls to see how field strength affected the statistical comparison. RCC did not differ with field strength, but again, which nodes differed between groups did. These results illustrate how one key parameter, scanner field strength, impacts rich club organization – a promising concept in brain connectomics research.

Original language	English (US)
Pages (from-to)	209-218
Number of pages	10
Journal	Mathematics and Visualization
Volume	0
DOIs	https://doi.org/10.1007/978-3-319-02475-2_19
State	Published - 2014
Event	16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013 - Nagoya, Japan Duration: Sep 22 2013 → Sep 26 2013

Bibliographical note

Publisher Copyright:
© Springer International Publishing Switzerland 2014.

Keywords

7T
Alzheimer’s
Connectivity
Connectome
DTI
Field strength
Rich club
Tractography

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10.1007/978-3-319-02475-2_19

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title = "Rich club analysis of structural brain connectivity at 7 tesla versus 3 tesla",

abstract = "The {\textquoteleft}rich club{\textquoteright} is a relatively new concept in brain connectivity analysis, which identifies a core of densely interconnected high-degree nodes. Establishing normative measures for rich club organization is vital, as is understanding how scanning parameters affect it.We compared the rich club organization in 23 subjects scanned at both 7 and 3 T, with 128-gradient high angular resolution diffusion imaging (HARDI). The rich club coefficient (RCC) did not differ significantly between low and high field scans, but the field strength did affect which nodes were included in the rich club. We also examined 3 subjects with Alzheimer{\textquoteright}s disease and 3 healthy elderly controls to see how field strength affected the statistical comparison. RCC did not differ with field strength, but again, which nodes differed between groups did. These results illustrate how one key parameter, scanner field strength, impacts rich club organization – a promising concept in brain connectomics research.",

keywords = "7T, Alzheimer{\textquoteright}s, Connectivity, Connectome, DTI, Field strength, Rich club, Tractography",

author = "Dennis, {Emily L.} and Liang Zhan and Neda Jahanshad and Mueller, {Bryon A.} and Yan Jin and Christophe Lenglet and Essa Yacoub and Guillermo Sapiro and Kamil Ugurbil and Noam Harel and Arthurw Toga and Lim, {Kelvin O.} and Thompson, {Paul M.}",

note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2014.; 16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013 ; Conference date: 22-09-2013 Through 26-09-2013",

year = "2014",

doi = "10.1007/978-3-319-02475-2_19",

language = "English (US)",

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T1 - Rich club analysis of structural brain connectivity at 7 tesla versus 3 tesla

AU - Dennis, Emily L.

AU - Zhan, Liang

AU - Jahanshad, Neda

AU - Mueller, Bryon A.

AU - Jin, Yan

AU - Lenglet, Christophe

AU - Yacoub, Essa

AU - Sapiro, Guillermo

AU - Ugurbil, Kamil

AU - Harel, Noam

AU - Toga, Arthurw

AU - Lim, Kelvin O.

AU - Thompson, Paul M.

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2014.

PY - 2014

Y1 - 2014

N2 - The ‘rich club’ is a relatively new concept in brain connectivity analysis, which identifies a core of densely interconnected high-degree nodes. Establishing normative measures for rich club organization is vital, as is understanding how scanning parameters affect it.We compared the rich club organization in 23 subjects scanned at both 7 and 3 T, with 128-gradient high angular resolution diffusion imaging (HARDI). The rich club coefficient (RCC) did not differ significantly between low and high field scans, but the field strength did affect which nodes were included in the rich club. We also examined 3 subjects with Alzheimer’s disease and 3 healthy elderly controls to see how field strength affected the statistical comparison. RCC did not differ with field strength, but again, which nodes differed between groups did. These results illustrate how one key parameter, scanner field strength, impacts rich club organization – a promising concept in brain connectomics research.

AB - The ‘rich club’ is a relatively new concept in brain connectivity analysis, which identifies a core of densely interconnected high-degree nodes. Establishing normative measures for rich club organization is vital, as is understanding how scanning parameters affect it.We compared the rich club organization in 23 subjects scanned at both 7 and 3 T, with 128-gradient high angular resolution diffusion imaging (HARDI). The rich club coefficient (RCC) did not differ significantly between low and high field scans, but the field strength did affect which nodes were included in the rich club. We also examined 3 subjects with Alzheimer’s disease and 3 healthy elderly controls to see how field strength affected the statistical comparison. RCC did not differ with field strength, but again, which nodes differed between groups did. These results illustrate how one key parameter, scanner field strength, impacts rich club organization – a promising concept in brain connectomics research.

KW - 7T

KW - Alzheimer’s

KW - Connectivity

KW - Connectome

KW - DTI

KW - Field strength

KW - Rich club

KW - Tractography

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U2 - 10.1007/978-3-319-02475-2_19

DO - 10.1007/978-3-319-02475-2_19

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AN - SCOPUS:84962841435

SN - 1612-3786

VL - 0

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JF - Mathematics and Visualization

T2 - 16th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2013

Y2 - 22 September 2013 through 26 September 2013

ER -

Rich club analysis of structural brain connectivity at 7 tesla versus 3 tesla

Abstract

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Keywords

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