Ribbon thickness influences fine generation during dry granulation

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Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.

Original languageEnglish (US)
Pages (from-to)87-88
Number of pages2
JournalInternational journal of pharmaceutics
Issue number1-2
StatePublished - Aug 30 2017


  • Dry granulation
  • Microcrystalline cellulose
  • Ribbon thickness
  • Roller compaction

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