TY - JOUR
T1 - Ribbon thickness influences fine generation during dry granulation
AU - Sun, Wei Jhe
AU - Sun, Changquan Calvin
PY - 2017/8/30
Y1 - 2017/8/30
N2 - Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.
AB - Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.
KW - Dry granulation
KW - Microcrystalline cellulose
KW - Ribbon thickness
KW - Roller compaction
UR - http://www.scopus.com/inward/record.url?scp=85021244318&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021244318&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2017.06.038
DO - 10.1016/j.ijpharm.2017.06.038
M3 - Article
C2 - 28619451
AN - SCOPUS:85021244318
VL - 529
SP - 87
EP - 88
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-2
ER -