Ribbon thickness influences fine generation during dry granulation

Wei Jhe Sun; Changquan Calvin Sun

doi:10.1016/j.ijpharm.2017.06.038

Ribbon thickness influences fine generation during dry granulation

Wei Jhe Sun, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.

Original language	English (US)
Pages (from-to)	87-88
Number of pages	2
Journal	International journal of pharmaceutics
Volume	529
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2017.06.038
State	Published - Aug 30 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

Dry granulation
Microcrystalline cellulose
Ribbon thickness
Roller compaction

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10.1016/j.ijpharm.2017.06.038

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title = "Ribbon thickness influences fine generation during dry granulation",

abstract = "Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.",

keywords = "Dry granulation, Microcrystalline cellulose, Ribbon thickness, Roller compaction",

author = "Sun, {Wei Jhe} and Sun, {Changquan Calvin}",

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year = "2017",

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AU - Sun, Changquan Calvin

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AB - Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.

KW - Dry granulation

KW - Microcrystalline cellulose

KW - Ribbon thickness

KW - Roller compaction

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Ribbon thickness influences fine generation during dry granulation

Abstract

Bibliographical note

Keywords

Publisher link

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