Ribbon thickness influences fine generation during dry granulation

Wei Jhe Sun; Changquan Calvin Sun

doi:10.1016/j.ijpharm.2017.06.038

Ribbon thickness influences fine generation during dry granulation

Wei Jhe Sun, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.

Original language	English (US)
Pages (from-to)	87-88
Number of pages	2
Journal	International journal of pharmaceutics
Volume	529
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ijpharm.2017.06.038
State	Published - Aug 30 2017

Keywords

Dry granulation
Microcrystalline cellulose
Ribbon thickness
Roller compaction

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10.1016/j.ijpharm.2017.06.038

Cite this

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title = "Ribbon thickness influences fine generation during dry granulation",

abstract = "Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.",

keywords = "Dry granulation, Microcrystalline cellulose, Ribbon thickness, Roller compaction",

author = "Sun, {Wei Jhe} and Sun, {Changquan Calvin}",

year = "2017",

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doi = "10.1016/j.ijpharm.2017.06.038",

language = "English (US)",

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T1 - Ribbon thickness influences fine generation during dry granulation

AU - Sun, Wei Jhe

AU - Sun, Changquan Calvin

PY - 2017/8/30

Y1 - 2017/8/30

N2 - Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.

AB - Uncontrolled fine generation during the milling process is a challenge for dry granulation by roller compaction. Here, we report the observation that ribbon thickness can significantly influence percentage of fines. Thus, among other parameters, ribbon thickness needs to be controlled for the development of a robust roller compaction process and ensure successful scale up.

KW - Dry granulation

KW - Microcrystalline cellulose

KW - Ribbon thickness

KW - Roller compaction

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JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

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