Ribbon density and milling parameters that determine fines fraction in a dry granulation

Wei Jhe Sun, Jukka Rantanen, Calvin Sun

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A challenge in the dry granulation (DG) process is the generation of an excessive amount of fines during milling, which can cause problems in die filling due to poor flowability and content uniformity of tablets. Using a design of experiments (DOE) approach, we show that the amount of fines generated during milling decreases with either increasing ribbon density or screen size, while impeller speed has negligible effect. Moreover, under identical milling conditions, the percent fines can be accurately predicted from ribbon density. Thus, controlling ribbon density and screen size is important for optimizing the amount of fines produced during DG process. Because density has a central role in the outcome, it is a critical ribbon property that needs to be controlled to improve robustness of the DG process.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalPowder Technology
Volume338
DOIs
StatePublished - Oct 2018

Bibliographical note

Funding Information:
W-J. Sun is grateful to the Department of Pharmaceutics, University of Minnesota for a David and Marilyn Grant Fellowship in Physical Pharmacy (2015–2017) and the Dane O. Kildsig Center for Pharmaceutical Processing Research (CPPR) for partial financial support. C.C. Sun thanks Lundbeckfonden and PhRMA Foundation for partial support to his sabbatical stay at the University of Copenhagen (2014–2015).

Publisher Copyright:
© 2018 Elsevier B.V.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

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