TY - JOUR
T1 - Rhodium(II)-catalyzed c-h functionalization of electron-deficient methyl groups
AU - Fu, Liangbing
AU - Guptill, David M.
AU - Davies, Huw M.L.
N1 - Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/5/11
Y1 - 2016/5/11
N2 - Enantioselective C-H functionalization of relatively electron-deficient methyl sites was achieved with the combination of 2,2,2-trichloroethyl aryldiazoacetates and tetrakis(triarylcyclopropanecarboxylate) dirhodium catalysts. The substrate scope of the transformation was relatively broad, and C-H functionalization products were furnished with excellent levels of enantioselectivity. As a strategic reaction, crotonate derivatives give 1,6-dicarbonyl compounds, which are useful for further diversification.
AB - Enantioselective C-H functionalization of relatively electron-deficient methyl sites was achieved with the combination of 2,2,2-trichloroethyl aryldiazoacetates and tetrakis(triarylcyclopropanecarboxylate) dirhodium catalysts. The substrate scope of the transformation was relatively broad, and C-H functionalization products were furnished with excellent levels of enantioselectivity. As a strategic reaction, crotonate derivatives give 1,6-dicarbonyl compounds, which are useful for further diversification.
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U2 - 10.1021/jacs.6b01941
DO - 10.1021/jacs.6b01941
M3 - Article
C2 - 27064173
AN - SCOPUS:84971221396
SN - 0002-7863
VL - 138
SP - 5761
EP - 5764
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 18
ER -